Advances in Management of Brain and Leptomeningeal Metastases.
Curr Neurol Neurosci Rep
; 20(7): 26, 2020 06 06.
Article
em En
| MEDLINE
| ID: mdl-32506161
ABSTRACT
PURPOSE OF REVIEW The management of brain and leptomeningeal metastases has changed significantly over the past decade. RECENT FINDINGS:
Historically, radiation therapy had been the mainstay of treatment. Several strategies to limit toxicities with radiation have been developed in the recent years. Increasingly systemic therapy options are being considered an important therapeutic option for CNS metastases. Numerous novel small molecule inhibitors and immunotherapy agents have intracranial activity to varying degrees, in addition to good extracranial disease control. Overall, the prognosis of select patients with CNS metastases has improved over the past several years with advent of new therapeutic strategies. Systemic therapy options with CNS benefit should be considered in select patients with small and asymptomatic CNS metastases. Further areas of research focus on molecular alterations predisposing to CNS metastases, identification of small molecule inhibitors with CNS activity, and the combination of radiation therapy and immunotherapy.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
/
Neoplasias do Sistema Nervoso Central
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Curr Neurol Neurosci Rep
Ano de publicação:
2020
Tipo de documento:
Article