Magnetoelectric Materials for Miniature, Wireless Neural Stimulation at Therapeutic Frequencies.
Neuron
; 107(4): 631-643.e5, 2020 08 19.
Article
em En
| MEDLINE
| ID: mdl-32516574
ABSTRACT
A major challenge for miniature bioelectronics is wireless power delivery deep inside the body. Electromagnetic or ultrasound waves suffer from absorption and impedance mismatches at biological interfaces. On the other hand, magnetic fields do not suffer these losses, which has led to magnetically powered bioelectronic implants based on induction or magnetothermal effects. However, these approaches have yet to produce a miniature stimulator that operates at clinically relevant high frequencies. Here, we show that an alternative wireless power method based on magnetoelectric (ME) materials enables miniature magnetically powered neural stimulators that operate up to clinically relevant frequencies in excess of 100 Hz. We demonstrate that wireless ME stimulators provide therapeutic deep brain stimulation in a freely moving rodent model for Parkinson's disease and that these devices can be miniaturized to millimeter-scale and fully implanted. These results suggest that ME materials are an excellent candidate to enable miniature bioelectronics for clinical and research applications.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estimulação Encefálica Profunda
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Neuroestimuladores Implantáveis
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Tecnologia sem Fio
Limite:
Animals
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Humans
Idioma:
En
Revista:
Neuron
Ano de publicação:
2020
Tipo de documento:
Article