Central nervous system neuroblastic tumor with FOXR2 activation presenting both neuronal and glial differentiation: a case report.
Brain Tumor Pathol
; 37(3): 100-104, 2020 Jul.
Article
em En
| MEDLINE
| ID: mdl-32535663
ABSTRACT
A subset of central nervous system neuroblastomas (CNS NB), rare primary embryonal CNS tumors, has been encompassed in CNS NB with FOXR2 activation (CNS NB-FOXR2) and usually shows the primitive neuronal architecture and occasional neurocytic differentiation. Here, we report a rare case of 3-year-old female with uncommon morphology of CNS embryonal tumor with FOXR2 activation presenting bidirectional differentiation to neurocytic small primitive cells and astrocytic spindle cells both of which are positive for synaptophysin and GFAP. Ultrastructural study also showed that there were presynaptic structure and intermediate filament in the tumor cells, suggesting glioneuronal differentiation. This case indicates the possibility of CNS neuroblastic tumor to differentiate neuronal and glial lineages.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Encefálicas
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Ativação Transcricional
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Neuroglia
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Fatores de Transcrição Forkhead
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Neuroblastoma
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Neurônios
Limite:
Child, preschool
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Female
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Humans
Idioma:
En
Revista:
Brain Tumor Pathol
Ano de publicação:
2020
Tipo de documento:
Article