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A lysosome-targeted ruthenium(II) polypyridyl complex as photodynamic anticancer agent.
Chen, Jun; Tao, Qin; Wu, Jian; Wang, Mengmeng; Su, Zhi; Qian, Yong; Yu, Tao; Wang, Yan; Xue, Xuling; Liu, Hong-Ke.
Afiliação
  • Chen J; Anhui Key Laboratory of Functional Coordination Compounds, School of Chemistry and Chemical Engineering, Anqing Normal University, Anqing, 246011, China; Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University,
  • Tao Q; Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
  • Wu J; Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
  • Wang M; Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
  • Su Z; Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
  • Qian Y; Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China.
  • Yu T; Department of Chemistry, University of North Dakota, 151 Cornell St., Grand Forks, ND 58202, USA.
  • Wang Y; Anhui Key Laboratory of Functional Coordination Compounds, School of Chemistry and Chemical Engineering, Anqing Normal University, Anqing, 246011, China. Electronic address: njwangy@live.com.
  • Xue X; Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China. Electronic address: xuexuling87@163.com.
  • Liu HK; Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210023, China. Electronic address: liuhongke@njnu.edu.cn.
J Inorg Biochem ; 210: 111132, 2020 09.
Article em En | MEDLINE | ID: mdl-32569884
ABSTRACT
Polypyridyl ruthenium complexes as novel photosensitizers had drawn attention due to its high selectivity towards cancer cells and low toxicity to normal cells. Herein, we synthesized a lysosome-targeted polypyridyl ruthenium complex Rhein-Ru(bpy)3 (bpy = 2,2'-bipyridine, rhein = 4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid), tethering with the Chinese medicine herb rhein. Rhein-Ru(bpy)3 exhibited high phototoxicity with short time of irradiation against tumor cell lines with the IC50 value of 2.4- 8.7 µM, and higher cytotoxicity against cisplatin-resistant A2780 cell lines, suggesting that Rhein-Ru(bpy)3 could overcome the cisplatin resistance. Moreover, Rhein-Ru(bpy)3 displayed low cytotoxicity towards cell lines in dark incubation, which was beneficial to reduce the toxic side effects towards normal cell lines. Besides, the confocal imaging and western blotting assay results suggested that Rhein-Ru(bpy)3 could induce cancer cell death through the autophagy pathway. These results inspired us that lysosome-targeted photosensitizers based on ruthenium complexes showed great potential for photodynamic therapy (PDT) application in cancer treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: 2,2'-Dipiridil / Fármacos Fotossensibilizantes / Complexos de Coordenação / Lisossomos / Antineoplásicos Limite: Humans Idioma: En Revista: J Inorg Biochem Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: 2,2'-Dipiridil / Fármacos Fotossensibilizantes / Complexos de Coordenação / Lisossomos / Antineoplásicos Limite: Humans Idioma: En Revista: J Inorg Biochem Ano de publicação: 2020 Tipo de documento: Article