Examination of preliminary behavioral and effective connectivity findings from treatment response to citalopram in cocaine use disorder: A dynamic causal modeling study.

Snyder, A D; Zuniga, E; Ma, L; Steinberg, J L; Woisard, K; Narayana, P A; Lane, S; Schmitz, J; Moeller, F G

Snyder, A D; Zuniga, E; Ma, L; Steinberg, J L; Woisard, K; Narayana, P A; Lane, S; Schmitz, J; Moeller, F G.

Afiliação

Snyder AD; Institute for Drug and Alcohol Studies; Department of Psychiatry. Electronic address: asnyder2@vcu.edu.
Zuniga E; Institute for Drug and Alcohol Studies.
Ma L; Institute for Drug and Alcohol Studies; Department of Radiology.
Steinberg JL; Institute for Drug and Alcohol Studies; Department of Psychiatry.
Woisard K; Institute for Drug and Alcohol Studies; Virginia Commonwealth University School of Medicine, Richmond, VA, United States.
Narayana PA; Department of Diagnostic and Interventional Imaging, University of Texas Health Science Center at Houston, Houston, TX, United States.
Lane S; Program in Neuroscience, Graduate School of Biomedical Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States.
Schmitz J; Faillace Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, Texas, United States.
Moeller FG; Institute for Drug and Alcohol Studies; Department of Psychiatry; Department of Pharmacology and Toxicology; Department of Neurology, Virginia Commonwealth University, Richmond, VA, United States. Electronic address: frederick.moeller@vcuhealth.org.

Psychiatry Res Neuroimaging ; 303: 111127, 2020 09 30.

Article em En | MEDLINE | ID: mdl-32593950

ABSTRACT

ABSTRACT

We sought effective (directional) connectivity parameters associated with response to citalopram in cocaine use disorder (CUD) by conducting a functional magnetic resonance imaging (fMRI) experiment with participants diagnosed with CUD (n = 13) and matched healthy controls (HC; n = 17). CUD participants showed a positive correlation between bilateral DLPFC-to-putamen effective connectivity and treatment effectiveness score. These preliminary results support further investigation of prefrontal-striatal interactions in response to treatment in CUD.

Assuntos

Citalopram/uso terapêutico; Transtornos Relacionados ao Uso de Cocaína/tratamento farmacológico; Corpo Estriado/efeitos dos fármacos; Imageamento por Ressonância Magnética/métodos; Córtex Pré-Frontal/efeitos dos fármacos; Inibidores Seletivos de Recaptação de Serotonina/uso terapêutico; Adulto; Citalopram/farmacologia; Transtornos Relacionados ao Uso de Cocaína/diagnóstico por imagem; Corpo Estriado/diagnóstico por imagem; Feminino; Humanos; Comportamento Impulsivo/efeitos dos fármacos; Comportamento Impulsivo/fisiologia; Masculino; Rede Nervosa/diagnóstico por imagem; Rede Nervosa/efeitos dos fármacos; Córtex Pré-Frontal/diagnóstico por imagem; Inibidores Seletivos de Recaptação de Serotonina/farmacologia; Resultado do Tratamento; Adulto Jovem

Palavras-chave

Citalopram; Cocaine use disorder; Effective connectivity; Impulsivity; Selective serotonin reuptake inhibitor; Ssri

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 2_ODS3 Base de dados: MEDLINE Assunto principal: Imageamento por Ressonância Magnética / Citalopram / Inibidores Seletivos de Recaptação de Serotonina / Córtex Pré-Frontal / Transtornos Relacionados ao Uso de Cocaína / Corpo Estriado Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Female / Humans / Male Idioma: En Revista: Psychiatry Res Neuroimaging Ano de publicação: 2020 Tipo de documento: Article

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