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PPARG Pro12Ala Polymorphism with CKD in Asians: A Meta-Analysis Combined with a Case-Control Study-A Key for Reaching Null Association.
Chen, Hsiang-Cheng; Chen, Wei-Teing; Sung, Tzu-Ling; Tsai, Dung-Jang; Lin, Chin; Su, Hao; Lin, Yuh-Feng; Chiu, Hung-Yi; Su, Sui-Lung.
Afiliação
  • Chen HC; Division of Rheumatology/Immunology/Allergy, Department of Internal Medicine, Tri Service, General Hospital, National Defense Medical Centre, Taipei 11490, Taiwan.
  • Chen WT; Division of Chest Medicine, Department of Medicine, Cheng Hsin General Hospital, Taipei 11220, Taiwan.
  • Sung TL; Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
  • Tsai DJ; School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan.
  • Lin C; School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan.
  • Su H; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan.
  • Lin YF; School of Public Health, National Defense Medical Center, Taipei 11490, Taiwan.
  • Chiu HY; Graduate Institute of Life Sciences, National Defense Medical Center, Taipei 11490, Taiwan.
  • Su SL; Department of Health Industry Management, Kainan University, Taoyuan 33857, Taiwan.
Genes (Basel) ; 11(6)2020 06 26.
Article em En | MEDLINE | ID: mdl-32604723
BACKGROUND: So far, numerous meta-analyses have been published regarding the correlation between peroxisome proliferator-activated receptor gamma (PPARG) proline 12 alanine (Pro12Ala) gene polymorphism and chronic kidney disease (CKD); however, the results appear to be contradictory. Hence, this study is formulated with the objective of using existing meta-analysis data together with our research population to study the correlation between PPARG Pro12Ala gene polymorphism and CKD and evaluate whether an accurate result can be obtained. METHODS: First, literature related to CKD and PPARG Pro12Ala available on the PubMed and EMBASE databases up to December 2016 was gathered from 20 publications. Then, the gathered results were combined with our case-control study of 1693 enrolled subjects and a trial sequential analysis (TSA) was performed to verify existing evidence and determine whether a firm conclusion can be drawn. RESULTS: The TSA results showed that the cumulative sample size for the Asian sample was 6078 and was sufficient to support a definite result. The results of this study confirmed that there is no obvious correlation between PPARG Pro12Ala and CKD for Asians (OR = 0.82 (95% CI = 0.66-1.02), I2 = 63.1%), but this was not confirmed for Caucasians. Furthermore, the case-control sample in our study was shown to be the key for reaching this conclusion. CONCLUSIONS: The meta-analysis results of this study suggest no significant correlation between PPARG Pro12Ala gene polymorphism and CKD for Asians after adding our samples, but not for Caucasian.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / PPAR gama / Insuficiência Renal Crônica / Estudos de Associação Genética Tipo de estudo: Observational_studies / Risk_factors_studies / Systematic_reviews Limite: Aged / Female / Humans / Male Idioma: En Revista: Genes (Basel) Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Predisposição Genética para Doença / PPAR gama / Insuficiência Renal Crônica / Estudos de Associação Genética Tipo de estudo: Observational_studies / Risk_factors_studies / Systematic_reviews Limite: Aged / Female / Humans / Male Idioma: En Revista: Genes (Basel) Ano de publicação: 2020 Tipo de documento: Article