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2'-O-Methyl at 20-mer Guide Strand 3' Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA.
Davis, Sarah M; Sousa, Jacquelyn; Vangjeli, Lorenc; Hassler, Matthew R; Echeverria, Dimas; Knox, Emily; Turanov, Anton A; Alterman, Julia F; Khvorova, Anastasia.
Afiliação
  • Davis SM; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Sousa J; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Vangjeli L; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Hassler MR; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Echeverria D; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Knox E; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Turanov AA; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Alterman JF; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA.
  • Khvorova A; RNA Therapeutics Institute, University of Massachusetts Medical School, Worcester, MA, USA; Department of Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: anastasia.khvorova@umassmed.edu.
Mol Ther Nucleic Acids ; 21: 266-277, 2020 Sep 04.
Article em En | MEDLINE | ID: mdl-32610253
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Mol Ther Nucleic Acids Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies Idioma: En Revista: Mol Ther Nucleic Acids Ano de publicação: 2020 Tipo de documento: Article