Pathomechanisms in schwannoma development and progression.
Oncogene
; 39(32): 5421-5429, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-32616891
ABSTRACT
Schwannomas are tumors of the peripheral nervous system, consisting of different cell types. These include tumorigenic Schwann cells, axons, macrophages, T cells, fibroblasts, blood vessels, and an extracellular matrix. All cell types involved constitute an intricate "tumor microenvironment" and play relevant roles in the development and progression of schwannomas. Although Nf2 tumor suppressor gene-deficient Schwann cells are the primary tumorigenic element and principle focus of current research efforts, evidence is accumulating regarding the contributory roles of other cell types in schwannoma pathology. In this review, we aim to provide an overview of intra- and intercellular mechanisms contributing to schwannoma formation. "Genes load the gun, environment pulls the trigger." -George A. Bray.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neurilemoma
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Oncogene
Ano de publicação:
2020
Tipo de documento:
Article