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Safety and immunogenicity of a Zika purified inactivated virus vaccine given via standard, accelerated, or shortened schedules: a single-centre, double-blind, sequential-group, randomised, placebo-controlled, phase 1 trial.
Stephenson, Kathryn E; Tan, Chen Sabrina; Walsh, Stephen R; Hale, Andrew; Ansel, Jessica L; Kanjilal, Diane G; Jaegle, Kate; Peter, Lauren; Borducchi, Erica N; Nkolola, Joseph P; Makoni, Tatenda; Fogel, Rachel; Bradshaw, Connor; Tyler, Anna; Moseley, Edward; Chandrashekar, Abishek; Yanosick, Katherine E; Seaman, Michael S; Eckels, Kenneth H; De La Barrera, Rafael A; Thompson, Jason; Dawson, Peter; Thomas, Stephen J; Michael, Nelson L; Modjarrad, Kayvon; Barouch, Dan H.
Afiliação
  • Stephenson KE; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA.
  • Tan CS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Walsh SR; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Hale A; University of Vermont Medical Center, Burlington, VT, USA; Larner College of Medicine, Burlington, VT, USA.
  • Ansel JL; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Kanjilal DG; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Jaegle K; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Peter L; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Borducchi EN; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Nkolola JP; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Makoni T; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Fogel R; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Bradshaw C; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Tyler A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Moseley E; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Chandrashekar A; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Yanosick KE; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Seaman MS; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA.
  • Eckels KH; Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • De La Barrera RA; Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Thompson J; Emmes, Rockville, MD, USA.
  • Dawson P; Emmes, Rockville, MD, USA.
  • Thomas SJ; Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Michael NL; Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Modjarrad K; Walter Reed Army Institute of Research, Silver Spring, MD, USA.
  • Barouch DH; Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Boston, MA, USA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA. Electronic address: dbarouch@bidmc.harvard.edu.
Lancet Infect Dis ; 20(9): 1061-1070, 2020 09.
Article em En | MEDLINE | ID: mdl-32618279
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Base de dados: MEDLINE Assunto principal: Vacinas Virais / Vacinas de Produtos Inativados / Zika virus / Infecção por Zika virus / Imunogenicidade da Vacina Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Infect Dis Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Base de dados: MEDLINE Assunto principal: Vacinas Virais / Vacinas de Produtos Inativados / Zika virus / Infecção por Zika virus / Imunogenicidade da Vacina Tipo de estudo: Clinical_trials Limite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Lancet Infect Dis Ano de publicação: 2020 Tipo de documento: Article