TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines.

Jiang, Yan-Yi; Jiang, Yuan; Li, Chun-Quan; Zhang, Ying; Dakle, Pushkar; Kaur, Harvinder; Deng, Jian-Wen; Lin, Ruby Yu-Tong; Han, Lin; Xie, Jian-Jun; Yan, Yiwu; Doan, Ngan; Zheng, Yueyuan; Mayakonda, Anand; Hazawa, Masaharu; Xu, Liang; Li, YanYu; Aswad, Luay; Jeitany, Maya; Kanojia, Deepika; Guan, Xin-Yuan; Said, Jonathan W; Yang, Wei; Fullwood, Melissa J; Lin, De-Chen; Koeffler, H Phillip

Jiang, Yan-Yi; Jiang, Yuan; Li, Chun-Quan; Zhang, Ying; Dakle, Pushkar; Kaur, Harvinder; Deng, Jian-Wen; Lin, Ruby Yu-Tong; Han, Lin; Xie, Jian-Jun; Yan, Yiwu; Doan, Ngan; Zheng, Yueyuan; Mayakonda, Anand; Hazawa, Masaharu; Xu, Liang; Li, YanYu; Aswad, Luay; Jeitany, Maya; Kanojia, Deepika; Guan, Xin-Yuan; Said, Jonathan W; Yang, Wei; Fullwood, Melissa J; Lin, De-Chen; Koeffler, H Phillip.

Afiliação

Jiang YY; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Jiang Y; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California; Cancer Science Institute of Singapore, National University of Singapore, Singapore. Electronic address: jiangyuanjy2016@gmail.com.
Li CQ; School of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing, China.
Zhang Y; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Dakle P; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Kaur H; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Deng JW; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Lin RY; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Han L; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Xie JJ; Department of Biochemistry and Molecular Biology, Medical College of Shantou University, Shantou, China.
Yan Y; Cedars-Sinai Medical Center, Departments of Surgery and Biomedical Sciences, Los Angeles, California.
Doan N; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Zheng Y; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California.
Mayakonda A; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Hazawa M; Cell-Bionomics Research Unit, Innovative Integrated Bio-Research Core, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, Ishikawa, Japan.
Xu L; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Li Y; School of Medical Informatics, Daqing Campus, Harbin Medical University, Daqing, China.
Aswad L; Cancer Science Institute of Singapore, National University of Singapore, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore.
Jeitany M; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Kanojia D; Cancer Science Institute of Singapore, National University of Singapore, Singapore.
Guan XY; Department of Clinical Oncology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Said JW; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Yang W; Cedars-Sinai Medical Center, Departments of Surgery and Biomedical Sciences, Los Angeles, California.
Fullwood MJ; Cancer Science Institute of Singapore, National University of Singapore, Singapore; School of Biological Sciences, Nanyang Technological University, Singapore. Electronic address: mfullwood@ntu.edu.sg.
Lin DC; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address: dchlin11@gmail.com.
Koeffler HP; Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California; Cancer Science Institute of Singapore, National University of Singapore, Singapore; National University Cancer Institute, National University Hospital Singapore, Singapore.

Gastroenterology ; 159(4): 1311-1327.e19, 2020 10.

Article em En | MEDLINE | ID: mdl-32619460

Assuntos

Epigênese Genética; Neoplasias Esofágicas/genética; Carcinoma de Células Escamosas do Esôfago/genética; Regulação Neoplásica da Expressão Gênica; Fatores de Transcrição Kruppel-Like/genética; Fatores de Transcrição SOXB1/genética; Fatores de Transcrição/genética; Transcrição Gênica; Proteínas Supressoras de Tumor/genética; Animais; Antineoplásicos/farmacologia; Linhagem Celular Tumoral; Proliferação de Células; Montagem e Desmontagem da Cromatina; Epigênese Genética/efeitos dos fármacos; Neoplasias Esofágicas/tratamento farmacológico; Neoplasias Esofágicas/metabolismo; Neoplasias Esofágicas/patologia; Carcinoma de Células Escamosas do Esôfago/tratamento farmacológico; Carcinoma de Células Escamosas do Esôfago/metabolismo; Carcinoma de Células Escamosas do Esôfago/patologia; Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos; Inibidores de Histona Desacetilases/farmacologia; Humanos; Fatores de Transcrição Kruppel-Like/metabolismo; Camundongos Endogâmicos NOD; Camundongos SCID; Proteínas/antagonistas & inibidores; Proteínas/metabolismo; Fatores de Transcrição SOXB1/metabolismo; Fatores de Transcrição/metabolismo; Transcrição Gênica/efeitos dos fármacos; Transcriptoma; Carga Tumoral; Proteínas Supressoras de Tumor/metabolismo; Ensaios Antitumorais Modelo de Xenoenxerto

Palavras-chave

ChIP-seq; Cistrome; Epigenome; Esophageal Cancer

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Fatores de Transcrição / Transcrição Gênica / Neoplasias Esofágicas / Regulação Neoplásica da Expressão Gênica / Proteínas Supressoras de Tumor / Epigênese Genética / Fatores de Transcrição Kruppel-Like / Fatores de Transcrição SOXB1 / Carcinoma de Células Escamosas do Esôfago Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Revista: Gastroenterology Ano de publicação: 2020 Tipo de documento: Article

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