When Is a Plasmodium-Infected Mosquito an Infectious Mosquito?
Trends Parasitol
; 36(8): 705-716, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-32620501
ABSTRACT
Plasmodium parasites experience significant bottlenecks as they transit through the mosquito and are transmitted to their mammalian host. Oocyst prevalence on mosquito midguts and sporozoite prevalence in salivary glands are nevertheless commonly used to confirm successful malaria transmission, assuming that these are reliable indicators of the mosquito's capacity to give rise to secondary infections. Here we discuss recent insights in sporogonic development and transmission bottlenecks for Plasmodium. We highlight critical gaps in our knowledge and frame their importance in understanding the human and mosquito reservoirs of infection. A better understanding of the events that lead to successful inoculation of infectious sporozoites by mosquitoes is critical to designing effective interventions to shrink the malaria map.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
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3_ND
Base de dados:
MEDLINE
Assunto principal:
Plasmodium
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Mosquitos Vetores
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Malária
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Anopheles
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
Idioma:
En
Revista:
Trends Parasitol
Ano de publicação:
2020
Tipo de documento:
Article