TAK­242 exerts a neuroprotective effect via suppression of the TLR4/MyD88/TRIF/NF­&#954;B signaling pathway in a neonatal hypoxic­ischemic encephalopathy rat model.

Jiang, Lijun; Xu, Zhenxing; Li, Hui; Wu, Mingfu; Wang, Fudong; Liu, Shunying; Tao, Jianlan; Feng, Xing

TAK242 exerts a neuroprotective effect via suppression of the TLR4/MyD88/TRIF/NFκB signaling pathway in a neonatal hypoxicischemic encephalopathy rat model.

Jiang, Lijun; Xu, Zhenxing; Li, Hui; Wu, Mingfu; Wang, Fudong; Liu, Shunying; Tao, Jianlan; Feng, Xing.

Afiliação

Jiang L; Department of Neonatology, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu 225000, P.R. China.
Xu Z; Department of Neonatology, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu 225000, P.R. China.
Li H; Department of Interventional Medicine, Yangzhou Hongquan Hospital, Yangzhou, Jiangsu 225200, P.R. China.
Wu M; Department of Neonatology, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu 225000, P.R. China.
Wang F; Department of Neonatology, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu 225000, P.R. China.
Liu S; Department of Neonatology, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu 225000, P.R. China.
Tao J; Department of Neonatology, Affiliated Hospital of Yangzhou University, Yangzhou, Jiangsu 225000, P.R. China.
Feng X; Department of Neonatology, Affiliated Children's Hospital of Soochow University, Suzhou, Jiangsu 215000, P.R. China.

Mol Med Rep ; 22(2): 1440-1448, 2020 08.

Article em En | MEDLINE | ID: mdl-32627010

Assuntos

Hipóxia-Isquemia Encefálica/tratamento farmacológico; Fármacos Neuroprotetores/uso terapêutico; Sulfonamidas/uso terapêutico; Receptor 4 Toll-Like; Proteínas Adaptadoras de Transporte Vesicular/metabolismo; Animais; Animais Recém-Nascidos; Citocinas/metabolismo; Modelos Animais de Doenças; Feminino; Fator 88 de Diferenciação Mieloide/metabolismo; NF-kappa B/metabolismo; Ratos; Ratos Sprague-Dawley; Receptor 4 Toll-Like/antagonistas & inibidores; Receptor 4 Toll-Like/metabolismo

Palavras-chave

TaK-242; Hie; Tlr4; nF-κB

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Sulfonamidas / Fármacos Neuroprotetores / Hipóxia-Isquemia Encefálica / Receptor 4 Toll-Like Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Mol Med Rep Ano de publicação: 2020 Tipo de documento: Article

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