1D, 1-Dimensional; 2D, 2-Dimensional; 3D, 3-Dimensional; AA, Amino Acid; BMRB, Biological Magnetic Resonance Data Bank; Corneal dystrophy; DMSO, Dimethyl sulfoxide; DSS, 4, 4-dimethyl-4-silapentane-1-sulfonic acid; EIC, Extracted Ion Chromatogram; EMI, Emilin-like domain; FAS1, Fasciclin like Domain; FPLC, Fast Protein Liquid Chromatography; Fragment screening; GCD, Granular Corneal Dystrophy; HPLC, High-performance liquid chromatography; HSQC, Heteronuclear Single Quantum Coherence Spectroscopy; IPTG, Isopropyl-beta-D-thiogalactopyranoside; ITC, Isothermal Titration Calorimetry; LB, Luria Bertani; LCD, Lattice Corneal Dystrophy; LE, Ligand Efficiency; MALDI, Matrix-Assisted Laser Desorption/Ionization; MS, Mass spectrometry/spectrometer; PBS, Phosphate Buffered Saline; Proteolysis; SD, Standard Deviation; SDS-PAGE, Sodium Dodecyl Sulphate-polyacrylamide gel electrophoresis; SPR, Surface Plasmon Resonance; TFA, Trifluoroacetic acid; TGFBI, Transforming Growth Factor Beta Induced; TGFBIp; TGFBIp, Transforming Growth Factor Beta Induced protein; TOF, Time-of-Flight; WAC, Weak affinity chromatography; WT, Wild Type; Weak affinity chromatography; ms, Millisecond