Tumor necrosis factor alpha (TNF-&#945;) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of preeclampsia.

Cunningham, Mark W; Jayaram, Aswathi; Deer, Evangeline; Amaral, Lorena M; Vaka, Venkata Ramana; Ibrahim, Tarek; Cornelius, Denise C; LaMarca, Babbette

Tumor necrosis factor alpha (TNF-α) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of preeclampsia.

Cunningham, Mark W; Jayaram, Aswathi; Deer, Evangeline; Amaral, Lorena M; Vaka, Venkata Ramana; Ibrahim, Tarek; Cornelius, Denise C; LaMarca, Babbette.

Afiliação

Cunningham MW; Department of Pharmacology & Toxicology, University of Mississippi Medical Center , Jackson, MS, USA.
Jayaram A; Department of Pharmacology & Toxicology, University of Mississippi Medical Center , Jackson, MS, USA.
Deer E; Department of Obstetrics and Gynecology, University of Mississippi Medical Center , Jackson, MS, USA.
Amaral LM; Department of Pharmacology & Toxicology, University of Mississippi Medical Center , Jackson, MS, USA.
Vaka VR; Department of Pharmacology & Toxicology, University of Mississippi Medical Center , Jackson, MS, USA.
Ibrahim T; Department of Pharmacology & Toxicology, University of Mississippi Medical Center , Jackson, MS, USA.
Cornelius DC; Department of Pharmacology & Toxicology, University of Mississippi Medical Center , Jackson, MS, USA.
LaMarca B; Department of Pharmacology & Toxicology, University of Mississippi Medical Center , Jackson, MS, USA.

Hypertens Pregnancy ; 39(4): 399-404, 2020 Nov.

Article em En | MEDLINE | ID: mdl-32646252

Assuntos

Pressão Sanguínea/efeitos dos fármacos; Etanercepte/uso terapêutico; Células Matadoras Naturais/efeitos dos fármacos; Mitocôndrias/efeitos dos fármacos; Estresse Oxidativo/efeitos dos fármacos; Pré-Eclâmpsia/tratamento farmacológico; Inibidores do Fator de Necrose Tumoral/uso terapêutico; Animais; Modelos Animais de Doenças; Etanercepte/farmacologia; Feminino; Mitocôndrias/metabolismo; Pré-Eclâmpsia/metabolismo; Gravidez; Ratos; Ratos Sprague-Dawley; Inibidores do Fator de Necrose Tumoral/farmacologia

Palavras-chave

Hypertension; inflammation and oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pré-Eclâmpsia / Pressão Sanguínea / Células Matadoras Naturais / Estresse Oxidativo / Etanercepte / Inibidores do Fator de Necrose Tumoral / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Animals / Pregnancy Idioma: En Revista: Hypertens Pregnancy Ano de publicação: 2020 Tipo de documento: Article

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