Vitamin C alleviates the senescence of periodontal ligament stem cells through inhibition of Notch3 during long-term culture.

Yang, Yan; Wang, Tao; Zhang, Sicheng; Jia, Sixun; Chen, Hong; Duan, Yufeng; Wang, Shikai; Chen, Guoqing; Tian, Weidong

Yang, Yan; Wang, Tao; Zhang, Sicheng; Jia, Sixun; Chen, Hong; Duan, Yufeng; Wang, Shikai; Chen, Guoqing; Tian, Weidong.

Afiliação

Yang Y; State Key Laboratory of Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Wang T; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Zhang S; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Jia S; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Chen H; State Key Laboratory of Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Duan Y; National Engineering Laboratory for Oral Regenerative Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Wang S; National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Chen G; Department of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Tian W; State Key Laboratory of Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

J Cell Physiol ; 236(2): 1237-1251, 2021 02.

Article em En | MEDLINE | ID: mdl-32662081

Assuntos

Ácido Ascórbico/administração & dosagem; Osteogênese/genética; Ligamento Periodontal/crescimento & desenvolvimento; Receptor Notch3/genética; Adolescente; Técnicas de Cultura de Células; Diferenciação Celular/efeitos dos fármacos; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Células Cultivadas; Criança; Feminino; Humanos; Masculino; Ligamento Periodontal/citologia; Ligamento Periodontal/metabolismo; Células-Tronco/citologia; Células-Tronco/efeitos dos fármacos

Palavras-chave

Notch3; cellular senescence; long-term culture; periodontal ligament stem cells; vitamin C

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteogênese / Ligamento Periodontal / Ácido Ascórbico / Receptor Notch3 Limite: Adolescent / Child / Female / Humans / Male Idioma: En Revista: J Cell Physiol Ano de publicação: 2021 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google