Mechanisms determining a differential threshold for sensing Src family kinase activity by B and T cell antigen receptors.

Borna, Simon; Fabisik, Matej; Ilievova, Kristyna; Dvoracek, Tomas; Brdicka, Tomas

Borna, Simon; Fabisik, Matej; Ilievova, Kristyna; Dvoracek, Tomas; Brdicka, Tomas.

Afiliação

Borna S; Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Science, Charles University, Prague, Czech Republic.
Fabisik M; Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Science, Charles University, Prague, Czech Republic.
Ilievova K; Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic; Faculty of Science, Charles University, Prague, Czech Republic.
Dvoracek T; Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
Brdicka T; Laboratory of Leukocyte Signaling, Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic. Electronic address: tomas.brdicka@img.cas.cz.

J Biol Chem ; 295(37): 12935-12945, 2020 09 11.

Article em En | MEDLINE | ID: mdl-32665402

Assuntos

Linfócitos B/metabolismo; Receptores de Antígenos de Linfócitos B/metabolismo; Receptores de Antígenos de Linfócitos T/metabolismo; Transdução de Sinais; Linfócitos T/metabolismo; Quinases da Família src/metabolismo; Humanos; Células Jurkat; Receptores de Antígenos de Linfócitos B/genética; Receptores de Antígenos de Linfócitos T/genética; Quinase Syk/genética; Quinase Syk/metabolismo; Proteína-Tirosina Quinase ZAP-70/genética; Proteína-Tirosina Quinase ZAP-70/metabolismo; Quinases da Família src/genética

Palavras-chave

B-cell receptor; SYK-family kinases; Src-family kinases; T-cell receptor (TCR); adaptor protein; calcium; inhibitor; receptor regulation; signal transduction; tyrosine-protein kinase (tyrosine kinase)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos B / Receptores de Antígenos de Linfócitos B / Receptores de Antígenos de Linfócitos T / Linfócitos T / Transdução de Sinais / Quinases da Família src Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2020 Tipo de documento: Article

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