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Inhibition of the ATR kinase enhances 5-FU sensitivity independently of nonhomologous end-joining and homologous recombination repair pathways.
Ito, Soichiro S; Nakagawa, Yosuke; Matsubayashi, Masaya; Sakaguchi, Yoshihiko M; Kobashigawa, Shinko; Matsui, Takeshi K; Nanaura, Hitoki; Nakanishi, Mari; Kitayoshi, Fumika; Kikuchi, Sotaro; Kajihara, Atsuhisa; Tamaki, Shigehiro; Sugie, Kazuma; Kashino, Genro; Takahashi, Akihisa; Hasegawa, Masatoshi; Mori, Eiichiro; Kirita, Tadaaki.
Afiliação
  • Ito SS; Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Nara, Japan.
  • Nakagawa Y; Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Nara, Japan.
  • Matsubayashi M; Department of Future Basic Medicine, Nara Medical University, Kashihara, Nara, Japan.
  • Sakaguchi YM; Department of Future Basic Medicine, Nara Medical University, Kashihara, Nara, Japan.
  • Kobashigawa S; Department of Future Basic Medicine, Nara Medical University, Kashihara, Nara, Japan.
  • Matsui TK; Department of Future Basic Medicine, Nara Medical University, Kashihara, Nara, Japan; Department of Neurology, Nara Medical University, Kashihara, Nara, Japan.
  • Nanaura H; Department of Future Basic Medicine, Nara Medical University, Kashihara, Nara, Japan; Department of Neurology, Nara Medical University, Kashihara, Nara, Japan.
  • Nakanishi M; Department of Future Basic Medicine, Nara Medical University, Kashihara, Nara, Japan.
  • Kitayoshi F; Department of Future Basic Medicine, Nara Medical University, Kashihara, Nara, Japan.
  • Kikuchi S; Department of Future Basic Medicine, Nara Medical University, Kashihara, Nara, Japan.
  • Kajihara A; Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Nara, Japan.
  • Tamaki S; Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Nara, Japan.
  • Sugie K; Department of Neurology, Nara Medical University, Kashihara, Nara, Japan.
  • Kashino G; Radioisotope Research Center, Nara Medical University, Kashihara, Nara, Japan.
  • Takahashi A; Gunma University Heavy Ion Medical Center, Maebashi, Gunma, Japan.
  • Hasegawa M; Department of Radiation Oncology, Nara Medical University, Kashihara, Nara, Japan.
  • Mori E; Department of Future Basic Medicine, Nara Medical University, Kashihara, Nara, Japan. Electronic address: emori@naramed-u.ac.jp.
  • Kirita T; Department of Oral and Maxillofacial Surgery, Nara Medical University, Kashihara, Nara, Japan. Electronic address: tkirita@naramed-u.ac.jp.
J Biol Chem ; 295(37): 12946-12961, 2020 09 11.
Article em En | MEDLINE | ID: mdl-32675286
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistencia a Medicamentos Antineoplásicos / Inibidores de Proteínas Quinases / Reparo do DNA por Junção de Extremidades / Reparo de DNA por Recombinação / Proteínas Mutadas de Ataxia Telangiectasia / Fluoruracila / Proteínas de Neoplasias / Neoplasias Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resistencia a Medicamentos Antineoplásicos / Inibidores de Proteínas Quinases / Reparo do DNA por Junção de Extremidades / Reparo de DNA por Recombinação / Proteínas Mutadas de Ataxia Telangiectasia / Fluoruracila / Proteínas de Neoplasias / Neoplasias Tipo de estudo: Diagnostic_studies Limite: Humans Idioma: En Revista: J Biol Chem Ano de publicação: 2020 Tipo de documento: Article