A strong preference for the TA/TA dinucleotide step discovered for an acridine-based, potent antitumor dsDNA intercalator, C-1305: NMR-driven structural and sequence-specificity studies.

Laskowski, Tomasz; Andralojc, Witold; Grynda, Jakub; Gwarda, Paulina; Mazerski, Jan; Gdaniec, Zofia

Laskowski, Tomasz; Andralojc, Witold; Grynda, Jakub; Gwarda, Paulina; Mazerski, Jan; Gdaniec, Zofia.

Afiliação

Laskowski T; Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Gabriela Narutowicza Str. 11/12, 80-233, Gdansk, Poland. tomasz.laskowski@pg.edu.pl.
Andralojc W; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Zygmunta Noskowskiego Str. 12/14, 61-704, Poznan, Poland. wandralojc@ibch.poznan.pl.
Grynda J; Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Gabriela Narutowicza Str. 11/12, 80-233, Gdansk, Poland.
Gwarda P; Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Gabriela Narutowicza Str. 11/12, 80-233, Gdansk, Poland.
Mazerski J; Department of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Gabriela Narutowicza Str. 11/12, 80-233, Gdansk, Poland.
Gdaniec Z; Institute of Bioorganic Chemistry, Polish Academy of Sciences, Zygmunta Noskowskiego Str. 12/14, 61-704, Poznan, Poland.

Sci Rep ; 10(1): 11697, 2020 07 16.

Article em En | MEDLINE | ID: mdl-32678133

Assuntos

Acridinas/química; Nucleotídeos de Adenina/química; Antineoplásicos/química; DNA/química; Descoberta de Drogas/métodos; Substâncias Intercalantes/química; Ressonância Magnética Nuclear Biomolecular/métodos; Nucleotídeos de Timina/química; Triazóis/química; Sequência de Bases; Sítios de Ligação; Ligantes; Modelos Moleculares; Simulação de Dinâmica Molecular; Conformação de Ácido Nucleico

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Nucleotídeos de Timina / Triazóis / Acridinas / DNA / Nucleotídeos de Adenina / Ressonância Magnética Nuclear Biomolecular / Descoberta de Drogas / Substâncias Intercalantes / Antineoplásicos Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article

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