Telomere shortening velocity of patients administered with hypnotics is accelerated in a gender-differential manner.
Can J Physiol Pharmacol
; 99(3): 278-283, 2021 Mar.
Article
em En
| MEDLINE
| ID: mdl-32687724
ABSTRACT
The telomere length and its distribution were compared between patients administered with and without hypnotics to see if regular administration of hypnotics is associated with their aging-related somatic telomere shortening. Male patients presented significant shortening of telomere length of circulating leukocytes in association with age (-41.9 bp/year, p = 0.045) in contrast with controls (-18.3 kb/year, p = 0.155). On the other hand, female patients presented no significant shortening of telomere length with aging (-16.4 bp/year, p = 0.372) in contrast with controls (-55.9 bp/year, p = 0.00005). These results suggested that regular administration of hypnotics is associated with aging progression in a gender-related manner. The administration of hypnotics could be an indicator as the somatic aging status and for the screening of background lifestyle-associated diseases promoting biological aging.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Encurtamento do Telômero
/
Hipnóticos e Sedativos
Aspecto:
Determinantes_sociais_saude
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Can J Physiol Pharmacol
Ano de publicação:
2021
Tipo de documento:
Article