Preparation, characterization and antibacterial activity of a novel soluble polymer derived from xanthone and O-carboxymethyl-N, N, N-trimethyl chitosan.
Int J Biol Macromol
; 164: 836-844, 2020 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-32693131
ABSTRACT
In this contribution, a novel soluble and antibacterial polymer, O-xanthonyl-chitosan (CTMC-Xan), was synthesized successfully by grafting 1,3-dihydroxy-xanthone (Xan) to the side chains of O-carboxymethyl-N, N, N-trimethyl chitosan (CTMC). The chemical structure and physical properties of the polymer were analyzed by 1H NMR, FT-IR spectra, UV spectra and XRD. The results showed that Xan could covalently bond with the carboxyl groups of CTMC by esterification at a grafting ratio of 9.1%. XRD patterns indicated that CTMC-Xan does not exhibit crystallization. The solubility tests showed that CTMC-Xan was completely dissolved and stable in neutral solution but unstable in acid or basic conditions. Moreover, it was found that the antibacterial activity against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) of CTMC-Xan was much stronger than that of Xan and CTMC, and the minimal bactericidal concentration (MBC) was 125 µg·mL-1. Due to the enhanced solubility and antibacterial activity, CTMC-Xan could potentially serve as a desirable biomaterial for food and pharmaceutical applications.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Xantonas
/
Quitosana
/
Antibacterianos
Limite:
Humans
Idioma:
En
Revista:
Int J Biol Macromol
Ano de publicação:
2020
Tipo de documento:
Article