The HLA-B*13:01 and the dapsone hypersensitivity syndrome in Korean and Asian populations: genotype- and meta-analyses.

ABSTRACT

BACKGROUND: The human leukocyte antigen (HLA)-B*1301 was reported as an important risk factor for dapsone hypersensitivity syndrome (DHS) in Chinese and Thai populations. RESEARCH DESIGN AND METHODS: From the Korean nationwide registry, seven subjects with previous DHS were included. Their HLA allele/phenotype frequencies were compared with 8 dapsone-tolerant subjects recruited from a single institution, and general population (n = 485) in Korea. The authors also performed a meta-analysis with these data using previous Chinese and Thai studies. RESULTS: Among the seven DHS subjects, 85.7% presented with the HLA-B*1301 allele. The HLA-C*0304, HLA-DRB1*1202 (both in linkage disequilibrium with HLA-B*1301), and HLA-A*0201 alleles were also presented in 85.7%, 71.4%, and 71.4%, respectively. Subjects with HLA-B*1301 were susceptible to developing DHS compared to dapsone-tolerant controls (odds ratio [OR] 73.667) and the Korean general population (OR 139.500). HLA-C*0304 (OR 40.935), HLA-DRB*1202 (OR 36.613), and HLA-A*0201 (OR 5.862) showed similar results. In meta-analysis, HLA-B*1301 was associated with dapsone-induced hypersensitivity (overall OR 42.692), and subgroup analyses according to the control types demonstrated similar results (OR43.694 and 41.866, respectively). CONCLUSIONS: Similar to previous Asian population studies, HLA-B*1301 is significantly associated with the risk of DHS in Korea. These associations may be useful for preventing DHS and improving drug safety.