Inhibition of Human Ether-A-Go-Go-Related Gene (hERG) Potassium Current by the Novel Sotalol Analogue, Soestalol.

Shugg, Tyler; Somberg, John C; Molnar, Janos; Overholser, Brian R

Shugg, Tyler; Somberg, John C; Molnar, Janos; Overholser, Brian R.

Afiliação

Shugg T; Department of Pharmacy Practice, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA; Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Somberg JC; Department of Medicine and Pharmacology, Rush University, Chicago, Illinois, USA; American Institute of Therapeutics, Lake Bluff, Illinois, USA.
Molnar J; American Institute of Therapeutics, Lake Bluff, Illinois, USA; Department of Medicine, Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, USA.
Overholser BR; Department of Pharmacy Practice, College of Pharmacy, Purdue University, West Lafayette, Indiana, USA; Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA. Electronic address: boverhol@purdue.edu.

JACC Clin Electrophysiol ; 6(7): 756-759, 2020 07.

Article em En | MEDLINE | ID: mdl-32703555

Assuntos

Potássio; Sotalol; Antiarrítmicos/farmacologia; Canais de Potássio Éter-A-Go-Go/genética; Éteres; Humanos; Sotalol/farmacologia

Palavras-chave

I(Kr); hERG; soestalol; sotalol; torsades de pointes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Potássio / Sotalol Limite: Humans Idioma: En Revista: JACC Clin Electrophysiol Ano de publicação: 2020 Tipo de documento: Article

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