Knockdown of Follistatin-like 1 disrupts synaptic transmission in hippocampus and leads to cognitive impairments.

Xiang, Shitong; Zhang, Yuying; Jiang, Tianyue; Ke, Ziying; Shang, Yingchun; Ning, Wen; Yang, Zhuo; Zhang, Tao

Xiang, Shitong; Zhang, Yuying; Jiang, Tianyue; Ke, Ziying; Shang, Yingchun; Ning, Wen; Yang, Zhuo; Zhang, Tao.

Afiliação

Xiang S; School of Medicine, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, PR China; College of Life Sciences and Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin 300071, PR China.
Zhang Y; College of Life Sciences and Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin 300071, PR China.
Jiang T; School of Medicine, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, PR China.
Ke Z; College of Life Sciences and Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin 300071, PR China.
Shang Y; College of Life Sciences and Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin 300071, PR China.
Ning W; College of Life Sciences and Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin 300071, PR China. Electronic address: ningwen108@nankai.edu.cn.
Yang Z; School of Medicine, State Key Laboratory of Medicinal Chemical Biology, Nankai University, Tianjin 300071, PR China. Electronic address: zhuoyang@nankai.edu.cn.
Zhang T; College of Life Sciences and Key Laboratory of Bioactive Materials Ministry of Education, Nankai University, Tianjin 300071, PR China. Electronic address: zhangtao@nankai.edu.cn.

Exp Neurol ; 333: 113412, 2020 11.

Article em En | MEDLINE | ID: mdl-32721453

Assuntos

Disfunção Cognitiva/genética; Disfunção Cognitiva/psicologia; Proteínas Relacionadas à Folistatina/fisiologia; Hipocampo/fisiologia; Transmissão Sináptica/fisiologia; Animais; Proteínas Relacionadas à Folistatina/genética; Expressão Gênica/genética; Ácido Glutâmico/fisiologia; Hipocampo/metabolismo; Aprendizagem; Memória/fisiologia; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Plasticidade Neuronal/genética; Técnicas de Patch-Clamp; Ácido gama-Aminobutírico/fisiologia

Palavras-chave

Cognitive impairment; Follistatin-like 1; Fstl1; Neural oscillation; RNA-Seq; Synaptic transmission; Transforming growth factor (TGF)-ß1-inducible gene

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transmissão Sináptica / Proteínas Relacionadas à Folistatina / Disfunção Cognitiva / Hipocampo Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Exp Neurol Ano de publicação: 2020 Tipo de documento: Article

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