Polydatin attenuates renal fibrosis in diabetic mice through regulating the Cx32-Nox4 signaling pathway.

Chen, Zhi-Quan; Sun, Xiao-Hong; Li, Xue-Juan; Xu, Zhan-Chi; Yang, Yan; Lin, Ze-Yuan; Xiao, Hai-Ming; Zhang, Meng; Quan, Shi-Jian; Huang, He-Qing

Chen, Zhi-Quan; Sun, Xiao-Hong; Li, Xue-Juan; Xu, Zhan-Chi; Yang, Yan; Lin, Ze-Yuan; Xiao, Hai-Ming; Zhang, Meng; Quan, Shi-Jian; Huang, He-Qing.

Afiliação

Chen ZQ; Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Sun XH; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Li XJ; Department of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning, 530021, China.
Xu ZC; Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Yang Y; Department of Pharmacy, Shenzhen Children's Hospital, Shenzhen, 518026, China.
Lin ZY; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, China.
Xiao HM; Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Zhang M; Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Quan SJ; Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.
Huang HQ; Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China.

Acta Pharmacol Sin ; 41(12): 1587-1596, 2020 Dec.

Article em En | MEDLINE | ID: mdl-32724174

Assuntos

Conexinas/metabolismo; Fibrose/tratamento farmacológico; Glucosídeos/uso terapêutico; Rim/efeitos dos fármacos; NADPH Oxidase 4/metabolismo; Transdução de Sinais/efeitos dos fármacos; Estilbenos/uso terapêutico; Animais; Diabetes Mellitus Experimental/complicações; Diabetes Mellitus Experimental/metabolismo; Diabetes Mellitus Experimental/patologia; Fibronectinas/metabolismo; Fibrose/etiologia; Fibrose/metabolismo; Fibrose/patologia; Molécula 1 de Adesão Intercelular/metabolismo; Rim/metabolismo; Rim/patologia; Masculino; Camundongos Endogâmicos C57BL; Estresse Oxidativo/efeitos dos fármacos; Ratos Sprague-Dawley; Ubiquitinação; Proteína beta-1 de Junções Comunicantes

Palavras-chave

Cx32; Nox4; diabetic nephropathy; oxidative stress; polydatin; renal fibrosis

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estilbenos / Fibrose / Transdução de Sinais / Conexinas / NADPH Oxidase 4 / Glucosídeos / Rim Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Acta Pharmacol Sin Ano de publicação: 2020 Tipo de documento: Article

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