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5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors.
Xu, Guozhang; Du, Fuyong; Kuo, Gee-Hong; Xu, June Zhi; Liang, Yin; Demarest, Keith; Gaul, Michael D.
Afiliação
  • Xu G; Discovery Sciences and Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, United States. Electronic address: gxu4@its.jnj.com.
  • Du F; Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, United States.
  • Kuo GH; Discovery Sciences and Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, United States.
  • Xu JZ; Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, United States.
  • Liang Y; Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, United States.
  • Demarest K; Cardiovascular & Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, United States.
  • Gaul MD; Discovery Sciences and Metabolic Research, Janssen Research & Development, L.L.C., Welsh & McKean Roads, Spring House, PA 19477, United States.
Bioorg Med Chem Lett ; 30(17): 127387, 2020 09 01.
Article em En | MEDLINE | ID: mdl-32738984
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transportador 1 de Glucose-Sódio / Transportador 2 de Glucose-Sódio / Glucosídeos / Hipoglicemiantes Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Transportador 1 de Glucose-Sódio / Transportador 2 de Glucose-Sódio / Glucosídeos / Hipoglicemiantes Limite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Lett Ano de publicação: 2020 Tipo de documento: Article