A blood miRNA signature associates with sporadic Creutzfeldt-Jakob disease diagnosis.

Norsworthy, Penny J; Thompson, Andrew G B; Mok, Tze H; Guntoro, Fernando; Dabin, Luke C; Nihat, Akin; Paterson, Ross W; Schott, Jonathan M; Collinge, John; Mead, Simon; Viré, Emmanuelle A

Norsworthy, Penny J; Thompson, Andrew G B; Mok, Tze H; Guntoro, Fernando; Dabin, Luke C; Nihat, Akin; Paterson, Ross W; Schott, Jonathan M; Collinge, John; Mead, Simon; Viré, Emmanuelle A.

Afiliação

Norsworthy PJ; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, Courtauld Building, 33 Cleveland Street, London, W1W 7FF, UK.
Thompson AGB; National Prion Clinic, National Hospital for Neurology and Neurosurgery, UCL Hospitals NHS Foundation Trust, Courtauld Building, 33 Cleveland Street, London, W1W 7FF, UK.
Mok TH; National Prion Clinic, National Hospital for Neurology and Neurosurgery, UCL Hospitals NHS Foundation Trust, Courtauld Building, 33 Cleveland Street, London, W1W 7FF, UK.
Guntoro F; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, Courtauld Building, 33 Cleveland Street, London, W1W 7FF, UK.
Dabin LC; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, Courtauld Building, 33 Cleveland Street, London, W1W 7FF, UK.
Nihat A; National Prion Clinic, National Hospital for Neurology and Neurosurgery, UCL Hospitals NHS Foundation Trust, Courtauld Building, 33 Cleveland Street, London, W1W 7FF, UK.
Paterson RW; Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Schott JM; Dementia Research Centre, UCL Institute of Neurology, University College London, Queen Square, London, WC1N 3BG, UK.
Collinge J; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, Courtauld Building, 33 Cleveland Street, London, W1W 7FF, UK.
Mead S; National Prion Clinic, National Hospital for Neurology and Neurosurgery, UCL Hospitals NHS Foundation Trust, Courtauld Building, 33 Cleveland Street, London, W1W 7FF, UK.
Viré EA; MRC Prion Unit at UCL, UCL Institute of Prion Diseases, Courtauld Building, 33 Cleveland Street, London, W1W 7FF, UK. s.mead@prion.ucl.ac.uk.

Nat Commun ; 11(1): 3960, 2020 08 07.

Article em En | MEDLINE | ID: mdl-32769986

Assuntos

Síndrome de Creutzfeldt-Jakob/sangue; Síndrome de Creutzfeldt-Jakob/genética; Perfilação da Expressão Gênica; MicroRNAs/sangue; MicroRNAs/genética; Idoso; Doença de Alzheimer/genética; Biomarcadores/sangue; Estudos de Coortes; Síndrome de Creutzfeldt-Jakob/diagnóstico; Síndrome de Creutzfeldt-Jakob/patologia; Progressão da Doença; Feminino; Regulação da Expressão Gênica; Humanos; Estudos Longitudinais; Masculino; Pessoa de Meia-Idade; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Curva ROC; Reprodutibilidade dos Testes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome de Creutzfeldt-Jakob / Perfilação da Expressão Gênica / MicroRNAs Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nat Commun Ano de publicação: 2020 Tipo de documento: Article

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