Balancing Altered Calcium Metabolism with Bone Health in Sarcoidosis.
Semin Respir Crit Care Med
; 41(5): 618-625, 2020 Oct.
Article
em En
| MEDLINE
| ID: mdl-32777848
ABSTRACT
Abnormal calcium metabolism in sarcoidosis patients can lead to hypercalcemia, hypercalciuria, and kidney stones. Hypercalcemia in sarcoidosis is usually due to increased activity of 1α-hydroxylase in macrophages of pulmonary granulomata, resulting in low levels of 25-hydroxyvitamin D and high levels of calcitriol. Vitamin D supplementation may be dangerous for some sarcoidosis patients and is recommended only for those with decreased 25-hydroxyvitamin D and reduced or normal calcitriol level. Diagnosis, treatment of osteoporosis, and maintenance of bone health are complex issues for sarcoidosis patients. An approach to diagnosis and treatment of bone fragility is presented.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sarcoidose
/
Vitamina D
/
Cálcio
/
Desmineralização Patológica Óssea
/
Suplementos Nutricionais
Tipo de estudo:
Clinical_trials
/
Etiology_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
Semin Respir Crit Care Med
Ano de publicação:
2020
Tipo de documento:
Article