Hunzeylanines A-E, Five Bisindole Alkaloids Tethered with a Methylene Group from the Roots of Hunteria zeylanica.
J Org Chem
; 85(16): 10884-10890, 2020 08 21.
Article
em En
| MEDLINE
| ID: mdl-32806090
ABSTRACT
Five novel bisindole alkaloids, hunzeylanines A-E (1-5), with an unprecedented skeleton were isolated from the roots of Hunteria zeylanica. Compounds 1-5 represent the first examples of akuammine-pleioarpamine-type bisindole alkaloids fused with a dihydropyran unit. Their structures including absolute configurations were established through comprehensive spectroscopic data analyses and computational calculation methods. The plausible biogenetic pathway of 1 was also proposed. Alkaloids 1 and 2 displayed moderate cytotoxicity toward three human cancer cell lines (MDA-MB-231, AV3, and Huh7).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Apocynaceae
/
Alcaloides
Limite:
Humans
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2020
Tipo de documento:
Article