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Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains.
La Sala, Grégory; Michiels, Camille; Kükenshöner, Tim; Brandstoetter, Tania; Maurer, Barbara; Koide, Akiko; Lau, Kelvin; Pojer, Florence; Koide, Shohei; Sexl, Veronika; Dumoutier, Laure; Hantschel, Oliver.
Afiliação
  • La Sala G; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL), Station 19, 1015, Lausanne, Switzerland.
  • Michiels C; Experimental Medicine Unit, De Duve Institute, Université catholique de Louvain, 1200, Brussels, Belgium.
  • Kükenshöner T; Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École polytechnique fédérale de Lausanne (EPFL), Station 19, 1015, Lausanne, Switzerland.
  • Brandstoetter T; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
  • Maurer B; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
  • Koide A; Department of Medicine, New York University School of Medicine, 522 1st Avenue, New York, 10016, NY, USA.
  • Lau K; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, 522 1st Avenue, New York, 10016, NY, USA.
  • Pojer F; Protein Crystallography Core Facility, School of Life Sciences, École polytechnique fédérale de Lausanne, Station 19, 1015, Lausanne, Switzerland.
  • Koide S; Protein Crystallography Core Facility, School of Life Sciences, École polytechnique fédérale de Lausanne, Station 19, 1015, Lausanne, Switzerland.
  • Sexl V; Laura and Isaac Perlmutter Cancer Center, New York University Langone Health, 522 1st Avenue, New York, 10016, NY, USA.
  • Dumoutier L; Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, 522 1st Avenue, New York, 10016, NY, USA.
  • Hantschel O; Institute of Pharmacology and Toxicology, University of Veterinary Medicine, Vienna, Austria.
Nat Commun ; 11(1): 4115, 2020 08 17.
Article em En | MEDLINE | ID: mdl-32807795

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Transcrição STAT3 / Anticorpos Limite: Humans Idioma: En Revista: Nat Commun Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator de Transcrição STAT3 / Anticorpos Limite: Humans Idioma: En Revista: Nat Commun Ano de publicação: 2020 Tipo de documento: Article