Calcium modulates the domain flexibility and function of an &#945;-actinin similar to the ancestral &#945;-actinin.

Pinotsis, Nikos; Zielinska, Karolina; Babuta, Mrigya; Arolas, Joan L; Kostan, Julius; Khan, Muhammad Bashir; Schreiner, Claudia; Salmazo, Anita; Ciccarelli, Luciano; Puchinger, Martin; Gkougkoulia, Eirini A; Ribeiro, Euripedes de Almeida; Marlovits, Thomas C; Bhattacharya, Alok; Djinovic-Carugo, Kristina

Calcium modulates the domain flexibility and function of an α-actinin similar to the ancestral α-actinin.

Pinotsis, Nikos; Zielinska, Karolina; Babuta, Mrigya; Arolas, Joan L; Kostan, Julius; Khan, Muhammad Bashir; Schreiner, Claudia; Salmazo, Anita; Ciccarelli, Luciano; Puchinger, Martin; Gkougkoulia, Eirini A; Ribeiro, Euripedes de Almeida; Marlovits, Thomas C; Bhattacharya, Alok; Djinovic-Carugo, Kristina.

Afiliação

Pinotsis N; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, A-1030 Vienna, Austria.
Zielinska K; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, A-1030 Vienna, Austria.
Babuta M; School of Life Sciences, Jawaharlal Nehru University, 110067 New Delhi, India.
Arolas JL; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, A-1030 Vienna, Austria.
Kostan J; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, A-1030 Vienna, Austria.
Khan MB; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, A-1030 Vienna, Austria.
Schreiner C; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, A-1030 Vienna, Austria.
Salmazo A; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, A-1030 Vienna, Austria.
Ciccarelli L; Centre for Structural Systems Biology, D-22607 Hamburg, Germany.
Puchinger M; Institute for Structure and Systems Biology, University Medical Center Hamburg-Eppendorf, D-20246 Hamburg, Germany.
Gkougkoulia EA; Deutsches Elektronen-Synchrotron, D-22607 Hamburg, Germany.
Ribeiro EA; Institute of Molecular Biotechnology, Austrian Academy of Sciences, A-1030 Vienna, Austria.
Marlovits TC; Research Institute of Molecular Pathology, A-1030 Vienna, Austria.
Bhattacharya A; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, A-1030 Vienna, Austria.
Djinovic-Carugo K; Department of Structural and Computational Biology, Max Perutz Labs, University of Vienna, A-1030 Vienna, Austria.

Proc Natl Acad Sci U S A ; 117(36): 22101-22112, 2020 09 08.

Article em En | MEDLINE | ID: mdl-32848067

Assuntos

Actinina/metabolismo; Cálcio/farmacologia; Entamoeba histolytica/metabolismo; Actinina/química; Actinina/genética; Domínio Catalítico; Entamoeba histolytica/genética; Regulação da Expressão Gênica; Modelos Moleculares; Conformação Proteica; Domínios Proteicos

Palavras-chave

F-actin bundling and binding; calcium regulation; crystal structure; modulation of structural rigidity; α-actinin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Actinina / Cálcio / Entamoeba histolytica Tipo de estudo: Prognostic_studies Idioma: En Revista: Proc Natl Acad Sci U S A Ano de publicação: 2020 Tipo de documento: Article

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