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Associations of Muscle Size and Density With Proximal Femur Bone in a Community Dwelling Older Population.
Yin, Lu; Xu, Zhengyang; Wang, Ling; Li, Wei; Zhao, Yue; Su, Yongbin; Sun, Wei; Liu, Yandong; Yang, Minghui; Yu, Aihong; Blake, Glen Mervyn; Wu, Xinbao; Veldhuis-Vlug, Annegreet G; Cheng, Xiaoguang; Hind, Karen; Engelke, Klaus.
Afiliação
  • Yin L; Medical Research & Biometrics Center, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Xu Z; Department of Radiology, The First Medical Center of Chinese PLA General Hospital, Beijing, China.
  • Wang L; Department of Radiology, Beijing Jishuitan Hospital, Beijing, China.
  • Li W; Medical Research & Biometrics Center, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Zhao Y; Department of Radiology, Beijing Jishuitan Hospital, Beijing, China.
  • Su Y; Department of Radiology, Beijing Jishuitan Hospital, Beijing, China.
  • Sun W; Xinjiekou Community Health Service Center, Beijing, China.
  • Liu Y; Department of Radiology, Beijing Jishuitan Hospital, Beijing, China.
  • Yang M; Department of Traumatic Orthopedics, Beijing Jishuitan Hospital, Beijing, China.
  • Yu A; Department of Radiology, Beijing Jishuitan Hospital, Beijing, China.
  • Blake GM; School of Biomedical Engineering & Imaging Sciences, King's College London, St Thomas' Hospital, London, United Kingdom.
  • Wu X; Department of Traumatic Orthopedics, Beijing Jishuitan Hospital, Beijing, China.
  • Veldhuis-Vlug AG; Division of Endocrinology, Department of Internal Medicine, Center for Bone Quality, Leiden University Medical Center (LUMC), Leiden, Netherlands.
  • Cheng X; Department of Radiology, Beijing Jishuitan Hospital, Beijing, China.
  • Hind K; Department of Sport and Exercise Sciences, Durham University, Durham, United Kingdom.
  • Engelke K; Department of Medicine 3, FAU University Erlangen-Nürnberg and Universitätsklinikum Erlangen, Erlangen, Germany.
Article em En | MEDLINE | ID: mdl-32849289
ABSTRACT
Background and

Purpose:

Muscle weakness and bone fragility are both associated with hip fracture. In general, muscle contractions create forces to the bone, and bone strength adapts to mechanical loading through changes in bone architecture and mass. However, the relationship between impairment of muscle and bone function remain unclear. In particular, the associations of muscle with properties of proximal femur cortical and trabecular bone are still not well understood. The aim of this study was to explore the associations of hip/thigh muscle density (CT attenuation value in Hounsfield units) and size with cortical and trabecular bone mineral density (BMD) of the proximal femur. Materials and

Methods:

Three-dimensional quantitative computed tomography (QCT) imaging of the lumber, hip and mid-thigh was performed in a total of 301 participants (mean age 68.4 ± 6.1 years, 194 women and 107 men) to derive areal BMD (aBMD) and volumetric BMD (vBMD). Handgrip strength (HGS) and the Timed Up and Go (TUG) test were also performed. From the CT images, cross-sectional area (CSA), and density were determined for the gluteus maximus muscle (G.MaxM), trunk muscle at the vertebrae L2 level, and mid-thigh muscle. Multivariate generalized linear models were applied to assess associations.

Results:

Total hip (TH) aBMD was associated significantly with G.MaxM CSA (men P = 0.042; women P < 0.001) and density (men P = 0.012; women P = 0.043). In women, 0.035 cm2 of mid-thigh CSA (95% CI, 0.014-0.057; P = 0.002) increased per SD increase in TH aBMD, but this significance was not observed in men (P = 0.095). Trunk muscle density and CSA were not associated with proximal femur BMD. The associations of hip/thigh muscle parameters with femoral neck BMD were weaker than those with trochanter and intertrochanter BMD. Furthermore, compared to muscle density, muscle CSA showed better associations with vBMD. G.MaxM CSA was associated with trochanter (TR) Cort. vBMD in men (ß, 19.898; 95% CI, 0.924-38.871; P = 0.040) and in women (ß, 15.426; 95% CI, 0.893-29.958; P = 0.038). Handgrip strength was only associated with TR aBMD (ß, 0.038; 95% CI, 0.006-0.070; P = 0.019) and intertrochanter aBMD (ß, 0.049; 95% CI, 0.009-0.090; P = 0.016) in men.

Conclusions:

We observed positive associations of the gluteus and thigh muscle size with proximal femur volumetric BMD. Specifically, the gluteus maximus muscle CSA was associated with trochanter cortical vBMD in both men and women.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Densidade Óssea / Força da Mão / Fêmur / Vida Independente / Fraturas por Osteoporose / Músculos Tipo de estudo: Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Endocrinol (Lausanne) Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Densidade Óssea / Força da Mão / Fêmur / Vida Independente / Fraturas por Osteoporose / Músculos Tipo de estudo: Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Front Endocrinol (Lausanne) Ano de publicação: 2020 Tipo de documento: Article