Apical Resection and Cryoinjury of Neonatal Mouse Heart.
Methods Mol Biol
; 2158: 23-32, 2021.
Article
em En
| MEDLINE
| ID: mdl-32857362
ABSTRACT
Neonatal mouse hearts have a regenerative capacity similar to adult zebrafish. Different cardiac injury models have been established to investigate the regenerative capacity of neonatal mouse hearts, including ventricular amputation, cryoinjury, and ligation of a major coronary artery. While the ventricular resection model can be utilized to study how tissue forms and regenerates de novo, cryoinjury and coronary artery ligation are methods that might better mimic myocardial infarction by creating tissue damage and necrosis as opposed to the removal of healthy tissue in the ventricular amputation model. Here we describe methods of creating ventricular resection and cardiac cryoinjury in newborn mice.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regeneração
/
Remodelação Ventricular
/
Criocirurgia
/
Coração
/
Traumatismos Cardíacos
/
Procedimentos Cirúrgicos Cardíacos
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Methods Mol Biol
Ano de publicação:
2021
Tipo de documento:
Article