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Targeting succinate dehydrogenase with malonate ester prodrugs decreases renal ischemia reperfusion injury.
Beach, Timothy E; Prag, Hiran A; Pala, Laura; Logan, Angela; Huang, Margaret M; Gruszczyk, Anja V; Martin, Jack L; Mahbubani, Krishnaa; Hamed, Mazin O; Hosgood, Sarah A; Nicholson, Michael L; James, Andrew M; Hartley, Richard C; Murphy, Michael P; Saeb-Parsy, Kourosh.
Afiliação
  • Beach TE; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Prag HA; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK.
  • Pala L; School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK.
  • Logan A; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK.
  • Huang MM; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Gruszczyk AV; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK.
  • Martin JL; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Mahbubani K; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Hamed MO; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Hosgood SA; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • Nicholson ML; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 0QQ, UK.
  • James AM; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK.
  • Hartley RC; School of Chemistry, University of Glasgow, Glasgow, G12 8QQ, UK.
  • Murphy MP; MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0XY, UK. Electronic address: mpm@mrc-mbu.cam.ac.uk.
  • Saeb-Parsy K; Department of Surgery and Cambridge NIHR Biomedical Research Centre, Biomedical Campus, University of Cambridge, Cambridge, CB2 0QQ, UK. Electronic address: ks10014@cam.ac.uk.
Redox Biol ; 36: 101640, 2020 09.
Article em En | MEDLINE | ID: mdl-32863205
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Traumatismo por Reperfusão Limite: Animals / Humans Idioma: En Revista: Redox Biol Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Pró-Fármacos / Traumatismo por Reperfusão Limite: Animals / Humans Idioma: En Revista: Redox Biol Ano de publicação: 2020 Tipo de documento: Article