Sarcoidosis and breast cancer: A retrospective case series.
Respir Med Case Rep
; 31: 101190, 2020.
Article
em En
| MEDLINE
| ID: mdl-32874910
ABSTRACT
BACKGROUND:
Sarcoidosis and breast cancer co-incidence is reported in the literature in the form of case reports.AIM:
To describe our experience from a single large sarcoidosis clinic.METHODS:
Retrospective chart review of 1000 sarcoidosis cases seen in our clinic from 2003 to 2008.RESULTS:
429/1000 female sarcoidosis cases were identified. Among them 20/429 had a history of sarcoidosis and breast cancer. In 12/20 breast cancer preceded sarcoidosis by 52 months, in 4/20 sarcoidosis preceded breast cancer by 200 months and in 4/20 they presented concurrently. Mean age of sarcoidosis diagnosis was 53.9 (±12.4) years. Majority were of European decent (16/20), 3 were African-Americans and 1 Asian. Scadding radiography stages distribution was (n) 4/11/3/2/0 for stages 0/I/II/III/IV respectively. They had 3.4 (±1.3) organs involved, mainly with intrathoracic involvement. 10/20 were asymptomatic and 11/20 received chronic treatment. Compared to 409 cases of sarcoidosis sine breast cancer (mean age 46.7 ± 13.1), sarcoidosis-breast cancer cases had sarcoidosis diagnosed at a significantly later age (p = 0.01). Histological diagnosis applied in all co-incidence cases, in 5 via mediastinoscopy.CONCLUSIONS:
Older females with breast cancer may develop sarcoidosis, with features indistinguishable from stand-alone sarcoidosis. When sarcoidosis is suspected histological diagnosis is mandatory.
Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Respir Med Case Rep
Ano de publicação:
2020
Tipo de documento:
Article