Physiologically Based Pharmacokinetic Modeling Involving Nonlinear Plasma and Tissue Binding: Application to Prednisolone and Prednisone in Rats.

Li, Xiaonan; DuBois, Debra C; Almon, Richard R; Jusko, William J

Li, Xiaonan; DuBois, Debra C; Almon, Richard R; Jusko, William J.

Afiliação

Li X; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (X.L., D.C.D., R.R.A., W.J.J.) and Department of Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York.
DuBois DC; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (X.L., D.C.D., R.R.A., W.J.J.) and Department of Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York.
Almon RR; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (X.L., D.C.D., R.R.A., W.J.J.) and Department of Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York.
Jusko WJ; Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences (X.L., D.C.D., R.R.A., W.J.J.) and Department of Biological Sciences (D.C.D., R.R.A.), State University of New York at Buffalo, Buffalo, New York wjjusko@buffalo.edu.

J Pharmacol Exp Ther ; 375(2): 385-396, 2020 11.

Article em En | MEDLINE | ID: mdl-32883831

Assuntos

Modelos Biológicos; Dinâmica não Linear; Prednisolona/sangue; Prednisolona/farmacocinética; Prednisona/sangue; Prednisona/farmacocinética; Animais; Masculino; Ratos; Ratos Wistar; Distribuição Tecidual

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Prednisolona / Prednisona / Dinâmica não Linear / Modelos Biológicos Limite: Animals Idioma: En Revista: J Pharmacol Exp Ther Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google