Alcohol Increases Exosome Release from Microglia to Promote Complement C1q-Induced Cellular Death of Proopiomelanocortin Neurons in the Hypothalamus in a Rat Model of Fetal Alcohol Spectrum Disorders.

Mukherjee, Sayani; Cabrera, Miguel A; Boyadjieva, Nadka I; Berger, Gregory; Rousseau, Bénédicte; Sarkar, Dipak K

Mukherjee, Sayani; Cabrera, Miguel A; Boyadjieva, Nadka I; Berger, Gregory; Rousseau, Bénédicte; Sarkar, Dipak K.

Afiliação

Mukherjee S; The Endocrine Program, Department of Animal Sciences, Rutgers, State University of New Jersey, New Brunswick, New Jersey 08901-1573.
Cabrera MA; The Endocrine Program, Department of Animal Sciences, Rutgers, State University of New Jersey, New Brunswick, New Jersey 08901-1573.
Boyadjieva NI; Endocrinology and Animal Biosciences Graduate Program, Rutgers, State University of New Jersey, New Brunswick, New Jersey 08901-1573.
Berger G; The Endocrine Program, Department of Animal Sciences, Rutgers, State University of New Jersey, New Brunswick, New Jersey 08901-1573.
Rousseau B; The Endocrine Program, Department of Animal Sciences, Rutgers, State University of New Jersey, New Brunswick, New Jersey 08901-1573.
Sarkar DK; Endocrinology and Animal Biosciences Graduate Program, Rutgers, State University of New Jersey, New Brunswick, New Jersey 08901-1573.

J Neurosci ; 40(41): 7965-7979, 2020 10 07.

Article em En | MEDLINE | ID: mdl-32887744

Assuntos

Depressores do Sistema Nervoso Central/farmacologia; Complemento C1q/farmacologia; Etanol/farmacologia; Exossomos/efeitos dos fármacos; Transtornos do Espectro Alcoólico Fetal/patologia; Microglia/efeitos dos fármacos; Pró-Opiomelanocortina/genética; Animais; Animais Recém-Nascidos; Morte Celular/efeitos dos fármacos; Células Cultivadas; Feminino; Transtornos do Espectro Alcoólico Fetal/metabolismo; Hipotálamo/metabolismo; Hipotálamo/patologia; Masculino; Neurônios/efeitos dos fármacos; Neurônios/metabolismo; Gravidez; Proteômica; Ratos; Ratos Sprague-Dawley; beta-Endorfina/metabolismo

Palavras-chave

apoptosis; complements; exosomes; fetal alcohol syndrome; microglia; proopiomelanocortin

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pró-Opiomelanocortina / Complemento C1q / Depressores do Sistema Nervoso Central / Microglia / Etanol / Exossomos / Transtornos do Espectro Alcoólico Fetal Tipo de estudo: Prognostic_studies Limite: Animals / Pregnancy Idioma: En Revista: J Neurosci Ano de publicação: 2020 Tipo de documento: Article

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