Inhibition of Histone Deacetylase 1 Prevents the Decrease in Titin (Connectin) Content and Development of Atrophy in Rat m. soleus after 3-Day Hindlimb Unloading.

Ulanova, A D; Gritsyna, Yu V; Bobylev, A G; Yakupova, E I; Zhalimov, V K; Belova, S P; Mochalova, E P; Nemirovskaya, T L; Shenkman, B S; Vikhlyantsev, I M

Ulanova, A D; Gritsyna, Yu V; Bobylev, A G; Yakupova, E I; Zhalimov, V K; Belova, S P; Mochalova, E P; Nemirovskaya, T L; Shenkman, B S; Vikhlyantsev, I M.

Afiliação

Ulanova AD; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Moscow, Russia.
Gritsyna YV; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Moscow, Russia.
Bobylev AG; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Moscow, Russia.
Yakupova EI; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Moscow, Russia.
Zhalimov VK; Institute of Cell Biophysics, Russian Academy of Sciences - a Separate Division of Federal Research Center Pushchino Scientific Center for Biological Research, Russian Academy of Sciences, Pushchino, Moscow region, Russia.
Belova SP; State Research Center Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Mochalova EP; State Research Center Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Nemirovskaya TL; State Research Center Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Shenkman BS; State Research Center Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Vikhlyantsev IM; Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Moscow, Russia. ivanvikhlyantsev@gmail.com.

Bull Exp Biol Med ; 169(4): 450-457, 2020 Aug.

Article em En | MEDLINE | ID: mdl-32889570

Assuntos

Benzamidas/farmacologia; Conectina/genética; Histona Desacetilase 1/genética; Inibidores de Histona Desacetilases/farmacologia; Atrofia Muscular/prevenção & controle; Fenilenodiaminas/farmacologia; Animais; Conectina/metabolismo; Regulação da Expressão Gênica; Membro Posterior; Elevação dos Membros Posteriores/efeitos adversos; Histona Desacetilase 1/antagonistas & inibidores; Histona Desacetilase 1/metabolismo; Masculino; Músculo Esquelético/efeitos dos fármacos; Músculo Esquelético/metabolismo; Músculo Esquelético/patologia; Atrofia Muscular/etiologia; Atrofia Muscular/genética; Atrofia Muscular/metabolismo; Tamanho do Órgão; Isoformas de Proteínas/genética; Isoformas de Proteínas/metabolismo; Ratos; Ratos Wistar; Transdução de Sinais

Palavras-chave

TTN gene; gravitational unloading; histone deacetylase 1; m. soleus; titin (connectin)

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 Base de dados: MEDLINE Assunto principal: Fenilenodiaminas / Benzamidas / Atrofia Muscular / Histona Desacetilase 1 / Inibidores de Histona Desacetilases / Conectina Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Revista: Bull Exp Biol Med Ano de publicação: 2020 Tipo de documento: Article

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