Evaluation of analgesic, sympathetic and motor effects of 1% and 2% lidocaine administered epidurally in dogs undergoing ovariohysterectomy.
Vet Anaesth Analg
; 47(6): 797-802, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-32900618
ABSTRACT
OBJECTIVE:
To compare, versus a control, the sensory, sympathetic and motor blockade of lidocaine 1% and 2% administered epidurally in bitches undergoing ovariohysterectomy. STUDYDESIGN:
Randomized, blinded, controlled clinical trial. ANIMALS A total of 24 mixed-breed intact female dogs.METHODS:
All dogs were administered dexmedetomidine, tramadol and meloxicam prior to general anesthesia with midazolam-propofol and isoflurane. Animals were randomly assigned for an epidural injection of lidocaine 1% (0.4 mL kg-1; group L1), lidocaine 2% (0.4 mL kg-1; group L2) or no injection (group CONTROL). Heart rate (HR), respiratory rate (fR), end-tidal partial pressure of carbon dioxide (Pe'CO2), and invasive systolic (SAP), mean (MAP) and diastolic (DAP) arterial pressures were recorded every 5 minutes. Increases in physiological variables were treated with fentanyl (3 µg kg-1) intravenously (IV). Phenylephrine (1 µg kg-1) was administered IV when MAP was <60 mmHg. Postoperative pain [Glasgow Composite Pain Score - Short Form (GCPS-SF)] and return of normal ambulation were recorded at 1, 2, 3, 4 and 6 hours after extubation.RESULTS:
There were no differences over time or among groups for HR, fR, Pe'CO2 and SAP. MAP and DAP were lower in epidural groups than in CONTROL (p = 0.0146 and 0.0047, respectively). There was no difference in the use of phenylephrine boluses. More fentanyl was administered in CONTROL than in L1 and L2 (p = 0.011). GCPS-SF was lower for L2 than for CONTROL, and lower in L1 than in both other groups (p = 0.001). Time to ambulation was 2 (1-2) hours in L1 and 3 (2-4) hours in L2 (p = 0.004). CONCLUSIONS AND CLINICAL RELEVANCE Epidural administration of lidocaine (0.4 mL kg-1) reduced fentanyl requirements and lowered MAP and DAP. Time to ambulation decreased and postoperative pain scores were improved by use of 1% lidocaine compared with 2% lidocaine.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Simpático
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Ovariectomia
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Histerectomia
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Anestesia Epidural
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Lidocaína
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Atividade Motora
Limite:
Animals
Idioma:
En
Revista:
Vet Anaesth Analg
Ano de publicação:
2020
Tipo de documento:
Article