Prospects and Pitfalls: Next-Generation Tools to Control Mosquito-Transmitted Disease.
Annu Rev Microbiol
; 74: 455-475, 2020 09 08.
Article
em En
| MEDLINE
| ID: mdl-32905752
ABSTRACT
Mosquito-transmitted diseases, including malaria and dengue, are a major threat to human health around the globe, affecting millions each year. A diverse array of next-generation tools has been designed to eliminate mosquito populations or to replace them with mosquitoes that are less capable of transmitting key pathogens. Many of these new approaches have been built on recent advances in CRISPR/Cas9-based genome editing. These initiatives have driven the development of pathogen-resistant lines, new genetics-based sexing methods, and new methods of driving desirable genetic traits into mosquito populations. Many other emerging tools involve microorganisms, including two strategies involving Wolbachia that are achieving great success in the field. At the same time, other mosquito-associated bacteria, fungi, and even viruses represent untapped sources of new mosquitocidal or antipathogen compounds. Although there are still hurdles to be overcome, the prospect that such approaches will reduce the impact of these diseases is highly encouraging.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
1_ASSA2030
/
2_ODS3
/
3_ND
/
4_TD
Base de dados:
MEDLINE
Assunto principal:
Controle de Doenças Transmissíveis
/
Controle de Mosquitos
/
Doenças Transmissíveis
/
Agentes de Controle Biológico
/
Culicidae
Aspecto:
Determinantes_sociais_saude
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Annu Rev Microbiol
Ano de publicação:
2020
Tipo de documento:
Article