Torsadogenic potential of a novel remyelinating drug clemastine for multiple sclerosis assessed in the rabbit proarrhythmia model.

Kawakami, Satoshi; Nagasawa, Yoshinobu; Hagiwara-Nagasawa, Mihoko; Omura, Kensuke; Aimoto, Megumi; Takahara, Akira

Kawakami, Satoshi; Nagasawa, Yoshinobu; Hagiwara-Nagasawa, Mihoko; Omura, Kensuke; Aimoto, Megumi; Takahara, Akira.

Afiliação

Kawakami S; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.
Nagasawa Y; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.
Hagiwara-Nagasawa M; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan; Department of Pharmacology, Faculty of Medicine, Toho University, Ota-ku, Tokyo 143-8540, Japan.
Omura K; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.
Aimoto M; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.
Takahara A; Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan. Electronic address: akirat@phar.toho-u.ac.jp.

J Pharmacol Sci ; 144(3): 123-128, 2020 Nov.

Article em En | MEDLINE | ID: mdl-32921393

Assuntos

Clemastina/administração & dosagem; Clemastina/efeitos adversos; Síndrome do QT Longo/induzido quimicamente; Esclerose Múltipla/tratamento farmacológico; Torsades de Pointes/induzido quimicamente; Potenciais de Ação/efeitos dos fármacos; Animais; Bloqueio Atrioventricular/fisiopatologia; Bradicardia/fisiopatologia; Relação Dose-Resposta a Droga; Canal de Potássio ERG1/antagonistas & inibidores; Ventrículos do Coração/efeitos dos fármacos; Infusões Intravenosas; Coelhos

Palavras-chave

Clemastine; Multiple sclerosis; QT-interval prolongation; Torsades de pointes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do QT Longo / Torsades de Pointes / Clemastina / Esclerose Múltipla Limite: Animals Idioma: En Revista: J Pharmacol Sci Ano de publicação: 2020 Tipo de documento: Article

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