Thiazolidin-2-cyanamides derivatives as novel potent <i>Escherichia coli</i> ß-glucuronidase inhibitors and their structure-inhibitory activity relationships.

Zhou, Tao-Shun; Wei, Bin; He, Min; Li, Ya-Sheng; Wang, Ya-Kun; Wang, Si-Jia; Chen, Jian-Wei; Zhang, Hua-Wei; Cui, Zi-Ning; Wang, Hong

Thiazolidin-2-cyanamides derivatives as novel potent Escherichia coli ß-glucuronidase inhibitors and their structure-inhibitory activity relationships.

Zhou, Tao-Shun; Wei, Bin; He, Min; Li, Ya-Sheng; Wang, Ya-Kun; Wang, Si-Jia; Chen, Jian-Wei; Zhang, Hua-Wei; Cui, Zi-Ning; Wang, Hong.

Afiliação

Zhou TS; College of Pharmaceutical Science and Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.
Wei B; College of Pharmaceutical Science and Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.
He M; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Lingnan Guangdong Laboratory of Modern Agriculture, Integrative Microbiology Research Centre, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guang
Li YS; College of Pharmaceutical Science and Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.
Wang YK; College of Pharmaceutical Science and Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.
Wang SJ; College of Pharmaceutical Science and Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.
Chen JW; Center for Human Nutrition, David Geffen School of Medicine, University of California, Los Angeles, CA, USA.
Zhang HW; College of Pharmaceutical Science and Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.
Cui ZN; College of Pharmaceutical Science and Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, China.
Wang H; State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Lingnan Guangdong Laboratory of Modern Agriculture, Integrative Microbiology Research Centre, Guangdong Province Key Laboratory of Microbial Signals and Disease Control, South China Agricultural University, Guang

J Enzyme Inhib Med Chem ; 35(1): 1736-1742, 2020 Dec.

Article em En | MEDLINE | ID: mdl-32928007

Assuntos

Cianamida/farmacologia; Escherichia coli/enzimologia; Glucuronidase/antagonistas & inibidores; Glicoproteínas/farmacologia; Tiazolidinas/farmacologia; Cianamida/química; Relação Dose-Resposta a Droga; Glucuronidase/metabolismo; Glicoproteínas/química; Simulação de Acoplamento Molecular; Estrutura Molecular; Relação Estrutura-Atividade; Tiazolidinas/química

Palavras-chave

Escherichia coli ß-glucuronidase; ß-glucuronidase inhibitors; CPT-11-induced toxicity; Structureinhibitory activity relationships; thiazolidin-2-cyanamide derivatives

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Glicoproteínas / Cianamida / Escherichia coli / Tiazolidinas / Glucuronidase Idioma: En Revista: J Enzyme Inhib Med Chem Ano de publicação: 2020 Tipo de documento: Article

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