Strategies for Discovering New Antibiotics from Bacteria in the Post-Genomic Era.
Curr Microbiol
; 77(11): 3213-3223, 2020 Nov.
Article
em En
| MEDLINE
| ID: mdl-32929578
ABSTRACT
New antibiotics are urgently required in clinical treatment and agriculture with the development of antimicrobial resistance. However, products discovered by repeating previous strategies are either not antibiotics or already known antibiotics. There is a growing demand for efficient strategies to discover new antibiotics. With the continuous improvement of gene sequencing technology and genomic data, some mining strategies have emerged. These strategies are expected to alleviate the current dilemma of antibiotics. In this review, we discuss the recent advances in discovery of bacterial antibiotics from the following aspects activation of silent gene clusters, genome mining and metagenome mining. In the future, we envision the discovery of natural antibiotic will be accelerated by the combination of these strategies.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Antibacterianos
Idioma:
En
Revista:
Curr Microbiol
Ano de publicação:
2020
Tipo de documento:
Article