Adhesion molecules before and after propylthiouracil in patients with subclinical hyperthyroidism.
Rev Assoc Med Bras (1992)
; 66(8): 1057-1061, 2020 Aug.
Article
em En
| MEDLINE
| ID: mdl-32935798
ABSTRACT
OBJECTIVE:
This study aimed to investigate the effect of propylthiouracil treatment on adhesion molecules in patients with subclinical hyperthyroidism.METHODS:
In this study, a total of 168 patients diagnosed with subclinical hyperthyroidism were treated with propylthiouracil for one year. The levels of adhesion molecules, consisting of sICAM-1, sVCAM-1, and sE-Selectin, before and after the treatment were measured and compared. These results were compared with the levels of 148 healthy controls who received a placebo.RESULTS:
sICAM-1 levels were significantly higher in subclinical hyperthyroidism patients than in healthy controls (*pa=0.000). sICAM-1 levels were significantly decreased after the treatment (**pb=0.000). Despite this decrease in patients with subclinical hyperthyroidism, it did not decrease to the level of the control group. sVCAM-1 did not change before and after propylthiouracil treatment. The level of sE-selectin was similar to that of the pretreatment control group, but it did not have statistical significance, although it increased after the treatment (**pb=0.004).CONCLUSION:
The sICAM level was significantly higher than the pretreatment values and decreased after the propylthiouracil treatment. However, further studies are needed to reduce the risk of atherosclerosis and cancer in patients with subclinical hyperthyroidism.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Propiltiouracila
/
Hipertireoidismo
Tipo de estudo:
Clinical_trials
Limite:
Humans
Idioma:
En
Revista:
Rev Assoc Med Bras (1992)
Ano de publicação:
2020
Tipo de documento:
Article