Signal dynamics of midbrain dopamine neurons during economic decision-making in monkeys.
Sci Adv
; 6(27)2020 07.
Article
em En
| MEDLINE
| ID: mdl-32937434
ABSTRACT
When we make economic choices, the brain first evaluates available options and then decides whether to choose them. Midbrain dopamine neurons are known to reinforce economic choices through their signal evoked by outcomes after decisions are made. However, although critical internal processing is executed while decisions are being made, little is known about the role of dopamine neurons during this period. We found that dopamine neurons exhibited dynamically changing signals related to the internal processing while rhesus monkeys were making decisions. These neurons encoded the value of an option immediately after it was offered and then gradually changed their activity to represent the animal's upcoming choice. Similar dynamics were observed in the orbitofrontal cortex, a center for economic decision-making, but the value-to-choice signal transition was completed earlier in dopamine neurons. Our findings suggest that dopamine neurons are a key component of the neural network that makes choices from values during ongoing decision-making processes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Tipo de estudo:
Health_economic_evaluation
/
Prognostic_studies
Idioma:
En
Revista:
Sci Adv
Ano de publicação:
2020
Tipo de documento:
Article