Nerolidol protects the liver against cyclophosphamide-induced hepatic inflammation, apoptosis, and fibrosis via modulation of Nrf2, NF-&#954;B p65, and caspase-3 signaling molecules in Swiss albino mice.

Iqubal, Ashif; Syed, Mansoor Ali; Ali, Javed; Najmi, Abul Kalam; Haque, Mohammad Mahfuzul; Haque, Syed Ehtaishamul

Nerolidol protects the liver against cyclophosphamide-induced hepatic inflammation, apoptosis, and fibrosis via modulation of Nrf2, NF-κB p65, and caspase-3 signaling molecules in Swiss albino mice.

Iqubal, Ashif; Syed, Mansoor Ali; Ali, Javed; Najmi, Abul Kalam; Haque, Mohammad Mahfuzul; Haque, Syed Ehtaishamul.

Afiliação

Iqubal A; Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.
Syed MA; Department of Biotechnology, Jamia Millia Islamia, New Delhi, India.
Ali J; Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.
Najmi AK; Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.
Haque MM; Department of Biotechnology, Jamia Millia Islamia, New Delhi, India.
Haque SE; Department of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.

Biofactors ; 46(6): 963-973, 2020 Nov.

Article em En | MEDLINE | ID: mdl-32941697

Assuntos

Caspase 3/metabolismo; Ciclofosfamida/administração & dosagem; Inflamação/prevenção & controle; Hepatopatias/prevenção & controle; Fator 2 Relacionado a NF-E2/metabolismo; Sesquiterpenos/farmacologia; Fator de Transcrição RelA/metabolismo; Animais; Apoptose; Modelos Animais de Doenças; Fibrose; Fígado/efeitos dos fármacos; Hepatopatias/patologia; Masculino; Camundongos; Transdução de Sinais/efeitos dos fármacos

Palavras-chave

Kuffer's cells; TGF-ß1; adjuvant drug; free radicals; inflammatory cytokines

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 6_ODS3_enfermedades_notrasmisibles Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Ciclofosfamida / Fator 2 Relacionado a NF-E2 / Fator de Transcrição RelA / Caspase 3 / Inflamação / Hepatopatias Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Revista: Biofactors Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google