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Two new 2-arylbenzofurans from Sesbania grandiflora L. and their cytotoxicity towards cancer cell.
Tjahjandarie, Tjitjik Srie; Tanjung, Mulyadi; Saputri, Ratih Dewi; Rahayu, Devina Oktari; Gunawan, Alfiah Nur Irza; Aldin, Muhammad Fajar.
Afiliação
  • Tjahjandarie TS; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
  • Tanjung M; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
  • Saputri RD; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
  • Rahayu DO; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
  • Gunawan ANI; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
  • Aldin MF; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
Nat Prod Res ; 35(24): 5637-5642, 2021 Dec.
Article em En | MEDLINE | ID: mdl-32945195
ABSTRACT
Two new 2-arylbenzofurans, sesbagrandiflorain D (1) and E (2) along with two known 2-arylbenzofurans, spinosan A (3) and spinosan B (4) were isolated from the stem bark of Sesbania grandiflora L. The structure of two new compounds established by HRESIMS, 1 D NMR (1H, 13C) and 2 D NMR (HMQC, HMBC) spectra. Compounds (1-4) assayed for their cytotoxicity towards three human cancer cells (MCF-7, HeLa, and WiDr). Compound 1 showed very high activity against MCF-7 and WiDr with an IC50 value of 0.06 and 0.60 µg/mL, respectively.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesbania / Neoplasias Limite: Humans Idioma: En Revista: Nat Prod Res Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sesbania / Neoplasias Limite: Humans Idioma: En Revista: Nat Prod Res Ano de publicação: 2021 Tipo de documento: Article