A sensitive liquid chromatography-tandem mass spectrometric method for determination of five ß-blockers after labeling with either hydrazonoyl chloride or dansyl chloride reagent.

Khedr, Alaa; Khayyat, Ahdab N; El-Shorbagi, Abdel-Nasser A; Kammoun, Ahmed K

Khedr, Alaa; Khayyat, Ahdab N; El-Shorbagi, Abdel-Nasser A; Kammoun, Ahmed K.

Afiliação

Khedr A; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, PO. Box 80260, Saudi Arabia. Electronic address: akhedr@kau.edu.sa.
Khayyat AN; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, PO. Box 80260, Saudi Arabia.
El-Shorbagi AA; Department of Medicinal Chemistry, Faculty of Pharmacy, Sharjah University, United Arab Emirates.
Kammoun AK; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, PO. Box 80260, Saudi Arabia.

J Chromatogr B Analyt Technol Biomed Life Sci ; 1160: 122383, 2020 Dec 01.

Article em En | MEDLINE | ID: mdl-32949926

Assuntos

Antagonistas Adrenérgicos beta/sangue; Cromatografia Líquida/métodos; Compostos de Dansil/química; Espectrometria de Massas em Tandem/métodos; Antagonistas Adrenérgicos beta/química; Animais; Limite de Detecção; Modelos Lineares; Coelhos; Reprodutibilidade dos Testes

Palavras-chave

Dansyl chloride; Hydrazonoyl chloride; Ionization suppression; Mass spectrometry; Matrix effect; Method sensitivity; ß-Blockers

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatografia Líquida / Antagonistas Adrenérgicos beta / Compostos de Dansil / Espectrometria de Massas em Tandem Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals Idioma: En Revista: J Chromatogr B Analyt Technol Biomed Life Sci Ano de publicação: 2020 Tipo de documento: Article

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