Effects of Cynara scolymus L. on glycemic indices:A systematic review and meta-analysis of randomized clinical trials.
Complement Ther Med
; 52: 102496, 2020 Aug.
Article
em En
| MEDLINE
| ID: mdl-32951745
ABSTRACT
OBJECTIVES:
Cynara scolymus L. (common artichoke) and its products have been considered as potential phytotherapeutic agents for various conditions, such as cardiovascular, hepatic and gastric diseases, among others. Until now, the effects of artichoke and artichoke products administration on glycemic indices have not been sufficiently appraised. The present study evaluated the effects of artichoke and artichoke products administration on the glycemic indices.METHODS:
Clinical trials were identified in the Cochrane Library, PubMed, Embase and Scopus databases; to infinity until 15 March 2020. Weighted mean differences (WMD) were pooled using a random-effects model. Heterogeneity, sensitivity analysis and publication bias were reported using standard methods.RESULTS:
Pooled analysis of nine Randomized controlled trials (RCTs), demonstrated that the administration of artichoke and artichoke products led to a significant reduced fasting blood sugar (FBS) (WMD -5.28 mg/dl, 95 % CI -8.95, -1.61; p = 0.005). However, other glycemic indeces including fasting insulin (WMD -0.45 µIU/dL, 95 % CI -1.14, 0.25; p = 0.20), HOMA-IR (MD -0.25, 95 % CI -0.57, 0.07; p = 0.12) or Hemoglobin A1c (HbA1c) (WMD -0.09, 95 % CI -0.20, 0.02; p = 0.09) did not alter after the administration of artichoke and artichoke products. A subgroup analysis comparing the kind of intervention, revealed that just the supplementation of artichoke and artichoke products, in a noco-supplementation form, was efficacy for the reduction of Homeostatic model assessment of insulin resistance (HOMA-IR) (WMD -0.52, 95 % CI -0.85, -0.19; p = 0.002).CONCLUSIONS:
The supplementation of artichoke and artichoke products can significantly reduce the FBS concentrations in humans. Moreover, these outcomes suggested that just the supplementation of artichoke and artichoke products is more effective in the reduction of HOMA-IR levels than the co-supplementation form. However, additional clinical trials with longer study periods are necessitated to obtain a robust conclusion for producing new guidelines as part of a healthy diet.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Suplementos Nutricionais
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Cynara scolymus
/
Índice Glicêmico
Tipo de estudo:
Clinical_trials
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Guideline
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Prognostic_studies
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Systematic_reviews
Limite:
Humans
Idioma:
En
Revista:
Complement Ther Med
Ano de publicação:
2020
Tipo de documento:
Article