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Cesarean section in reducing mother-to-child HBV transmission: a meta-analysis.
He, Rongfang; Wen, Ping; Xiong, Mei; Fan, Zenan; Li, Fang; Luo, Dan; Xie, Xin.
Afiliação
  • He R; Department of Infectious Disease, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • Wen P; Department of Psychiatry, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • Xiong M; Department of Nursing, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • Fan Z; Sichuan Clinical Research Center for Birth Defects, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • Li F; Sichuan Clinical Research Center for Birth Defects, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • Luo D; Department of Pediatrics, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
  • Xie X; Department of Pediatric Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
J Matern Fetal Neonatal Med ; 35(18): 3424-3432, 2022 Sep.
Article em En | MEDLINE | ID: mdl-32954878
BACKGROUND: A meta-analysis (MA) of natural vs. cesarean births in HBV infected mothers was performed to assess which delivery methods could minimize the mother-to-child transmission (MTCT) of Hepatitis B virus (HBV). METHODS: Electrical databases PubMed, Embase and Cochrane Library were searched for the English papers about the HBV MTCT up to 19 August 2019. STATA 11.0 software was used for all analysis. Odds ratio (OR) and 95% confidence interval (CI) were used to present the effect size for MTCT at birth and MTCT more than 6 months. Heterogeneity was evaluated using the chi-squared Q and I2 test to determine the use of random effects model or fixed effects model. RESULTS: A total of 19 articles involving 11,144 HBV-positive pregnant women (5251 underwent natural delivery and 5893 received a cesarean section) were included in the study. The pooled OR for MTCT at birth was 0.42, 95% CI: 0.23-0.76 based on random effect model (I2 = 69.9%, p = .019). Meanwhile, in fixed effect model (I2 = 0.0%, p = .470), the pooled OR for MTCT more than 6 months was 0.62, 95% CI: 0.48-0.81. The results indicated that HBV infection in cesarean births significantly lower than that of vaginal delivery. Subgroup analysis of MTCT more than 6 months was clearly, and the results indicated that cesarean section significantly reduced the risk of MTCT (OR = 0.62, 95% CI: 0.48-0.81, p < .001). CONCLUSIONS: Cesarean section can reduce the risk of HBV MTCT and should be employed as a preventive measure. Due to the limitations of this study, further multi-center, large-sample randomized controlled trials must be performed to confirm these findings.
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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Hepatite B Tipo de estudo: Clinical_trials / Prognostic_studies / Systematic_reviews Limite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: J Matern Fetal Neonatal Med Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 1_ASSA2030 / 2_ODS3 Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Hepatite B Tipo de estudo: Clinical_trials / Prognostic_studies / Systematic_reviews Limite: Female / Humans / Newborn / Pregnancy Idioma: En Revista: J Matern Fetal Neonatal Med Ano de publicação: 2022 Tipo de documento: Article