Hereditary hemochromatosis promotes colitis and colon cancer and causes bacterial dysbiosis in mice.

Sivaprakasam, Sathish; Ristic, Bojana; Mudaliar, Nithya; Hamood, Abdul N; Colmer-Hamood, Jane; Wachtel, Mitchell S; Nevels, Anna G; Kottapalli, Kameswara R; Ganapathy, Vadivel

Sivaprakasam, Sathish; Ristic, Bojana; Mudaliar, Nithya; Hamood, Abdul N; Colmer-Hamood, Jane; Wachtel, Mitchell S; Nevels, Anna G; Kottapalli, Kameswara R; Ganapathy, Vadivel.

Afiliação

Sivaprakasam S; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, U.S.A.
Ristic B; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, U.S.A.
Mudaliar N; Department of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX, U.S.A.
Hamood AN; Department of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX, U.S.A.
Colmer-Hamood J; Department of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, TX, U.S.A.
Wachtel MS; Department of Pathology, Texas Tech University Health Sciences Center, Lubbock, TX, U.S.A.
Nevels AG; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, U.S.A.
Kottapalli KR; Center for Biotechnology and Genomics, Texas Tech University, Lubbock, TX, U.S.A.
Ganapathy V; Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX, U.S.A.

Biochem J ; 477(19): 3867-3883, 2020 10 16.

Article em En | MEDLINE | ID: mdl-32955078

Assuntos

Colite; Neoplasias do Colo; Disbiose; Microbioma Gastrointestinal; Hemocromatose; Proteobactérias/crescimento & desenvolvimento; Animais; Colite/genética; Colite/metabolismo; Colite/microbiologia; Colite/patologia; Neoplasias do Colo/genética; Neoplasias do Colo/metabolismo; Neoplasias do Colo/microbiologia; Neoplasias do Colo/patologia; Disbiose/genética; Disbiose/metabolismo; Disbiose/microbiologia; Disbiose/patologia; Hemocromatose/genética; Hemocromatose/metabolismo; Hemocromatose/microbiologia; Hemocromatose/patologia; Proteína da Hemocromatose/deficiência; Proteína da Hemocromatose/metabolismo; Camundongos; Camundongos Knockout; Proteobactérias/classificação

Palavras-chave

HFE-null mouse; colitis; colon cancer; dysbiosis; hemochromatosis; iron/heme overload

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Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: MEDLINE Assunto principal: Colite / Neoplasias do Colo / Proteobactérias / Disbiose / Microbioma Gastrointestinal / Hemocromatose Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Revista: Biochem J Ano de publicação: 2020 Tipo de documento: Article

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